Join the bit.bio team

Cambridge Start Up of the Year 2018

bit.bio is an award-winning spinout from the University of Cambridge. Our breakthrough technology combines synthetic and stem cell biology for the precise, efficient and consistent reprogramming of human cells used in research, drug discovery, and cell therapy. At bit.bio, we are passionate about engineering human cells that will enable the medicine of the future. To do this we need talented and curious people who want to make an impact on the future of science and therapeutics.

As a team of individuals, we value science, collaboration, openness, curiosity and creativity. We are united by trust and respect for each other.

bit.bio provides a vibrant and dynamic work environment in an exciting, fast-moving time for biology. We work with cutting edge technologies and with our world-leading scientific advisory board. We conduct pioneering work with real-world impact.

We trust our people to make significant contributions early on with opportunities to be involved in projects that are key to the success and growth of our young company. We invest in people, creating opportunities for personal development in an inclusive multi-skilled team with ambitious goals that provide opportunities to learn on the job from each other.

Creativity and open minds are encouraged for everyone to contribute to the success of the company.

To support bit.bio staff and our culture further, we also offer a competitive salary, highly competitive benefits package including pension contribution scheme as well as health and life insurance.

To be part of our dynamic, growing start-up team and share our vision to build together the leading cell coding company, please send your CV and cover letter to careers@bit.bio

 

Senior Scientist – Stem Cell and Neurodevelopmental Biology

Location: Babraham Research Campus, Cambridge
Type: Full time, permanent | Start: Immediate
Salary: Competitive | Hours: 40 p/w
Lab Based Position

 

Your role in our team:

We are looking for Scientists that has a solid understanding of the molecular principles underlying the specification of glial lineages, especially astrocytes, and experience with the generation of these cell types from iPSCs. Reporting to our CNS lead and Head of Research, the candidate will work with a team of R&D scientists and external collaborators to support our efforts to develop and validate a range of new human iPSC-derived neurons.

 

Your key responsibilities will include:

  • Advising, designing and executing reprogramming strategies to obtain pure and well-defined populations of human iPSC-derived glia cells.
  • Supporting collaboration with external partners to develop and characterise new cell types and disease models.
  • Supervising research assistants to deliver R&D programs in a timely manner.
  • Working closely with the product development team and product management to meet new product launch timelines.
  • Supporting the company in drafting and putting together proposals.

You…

  • Have a PhD in human pluripotent stem cell derived models for neurobiology, and an additional 3 years of experience with iPSC-derived glia cells in an academic or industrial setting.
  • Are driven by scientific excellence and are a keen experimentalist with strong attention to details and organisational skills.
  • Have hands on experience in collaborative project management.
  • Are a keen team player who will enjoy working at the interface of the wider science team to support the company’s cell type development efforts, with all the multitasking and communication skills that it requires.
  • Enjoy tackling research challenges through critical thinking and inventiveness, demonstrating the highest scientific rigour and work standards.
  • Are comfortable and used to working to tight timelines and managing workload and priorities.

Essential for the role:

  • Broad knowledge about the molecular mechanisms that define cellular identities in the CNS and the use of iPSC-derived glia cells in disease modelling.
  • Published relevant work in peer-reviewed journals, preferably first or last authorships.
  • Highly skilled in culturing human pluripotent stem cells and iPSC-derived glia cells, preferably astrocytes.
  • Experience in cell characterisation methods (ICC, qPCR and other assays).
  • Project management experience with internal and external stakeholders.
  • Supervisory and training experience.

… and possibly…

  • NGS experience (experimental design, library preparation and/or data analysis).
  • Functional characterisation of glia cells.
  • Extensive network in the field of neuroscience to facilitate collaborations with external partners.

 

You are welcome to apply

To be part of our dynamic, growing start-up team and share our vision to build together the leading cell coding company please send your CV and cover letter to careers@bit.bio

 

Scientist – Stem Cell and Neurodevelopmental Biology

Location: Babraham Research Campus, Cambridge
Type: Full time, permanent | Start: Immediate
Salary: Competitive | Hours: 40 p/w
Lab Based Position

 

Your role in our team:

We are looking for Scientists that has a solid understanding of the molecular principles underlying the specification of neuronal and/or glial lineages and experience with the generation of these cell types from iPSCs. Reporting to our CNS lead and Head of Research, the candidate will work with a team of R&D scientists and external collaborators to support our efforts to develop and validate a range of new human iPSC-derived neurons.

 

Your key responsibilities will include:

  • Advising, designing and executing reprogramming strategies to obtain pure and well-defined populations of human iPSC-derived neurons and/or glia cells.
  • Supporting collaboration with external partners to develop and characterise new cell types and disease models.
  • Supervising research assistants to deliver R&D programs in a timely manner.
  • Working closely with the product development team and product management to meet new product launch timelines.
  • Supporting the company in drafting and putting together proposals.

You…

  • Have a PhD in human pluripotent stem cell derived models for neurobiology.
  • Are driven by scientific excellence and are a keen experimentalist with strong attention to details and organisational skills.
  • Have hands on experience in collaborative project management.
  • Are a keen team player who will enjoy working at the interface of the wider science team to support the company’s cell type development efforts, with all the multitasking and communication skills that it requires.
  • Enjoy tackling research challenges through critical thinking and inventiveness, demonstrating the highest scientific rigour and work standards.
  • Are comfortable and used to working to tight timelines and managing workload and priorities.

Essential for the role:

  • Broad knowledge about the molecular mechanisms that define cellular identities in the CNS and the use of iPSC-derived neurons in disease modelling.
  • Published relevant work in peer-reviewed journals.
  • Highly skilled in culturing human pluripotent stem cells and iPSC-derived neurons and/or glia cells.
  • Experience in cell characterisation methods (ICC, qPCR and other assays).
  • Project management experience with internal and external stakeholders .

… and possibly…

  • NGS experience (experimental design, library preparation and/or data analysis).
  • Functional characterisation of neurons and/or glia cells.
  • Extensive network in the field of neuroscience to facilitate collaborations with external partners.

 

You are welcome to apply

To be part of our dynamic, growing start-up team and share our vision to build together the leading cell coding company please send your CV and cover letter to careers@bit.bio

 

Research Assistant – Cell Biology (Neuroscience)

Location: Babraham Research Campus, Cambridge
Type: Full time, permanent | Start: Immediate
Salary: Competitive | Hours: 40 p/w
Lab Based Position

 

Your role in our team:

To support the execution of our ambitious research programmes for generating human cell type diversity by cellular reprogramming, we are looking for motivated and skilled assistant scientists to join our growing science team as part of our neuroscience programme. You will become a key player in the delivery of strategic research activities, being involved in the design, execution and reporting of experimental work. This is an opportunity to join one of the best stem cell reprogramming labs and conduct research with a real-world impact.

 

Your key responsibilities will include:

  • Working collaboratively with the wider team under supervision of senior scientists.
  • Design and execution of experiments, analysis and reporting of results.
  • Providing technical and scientific expertise to the R&D team by contributing to protocol development and diffusion.
  • Working with the wider team to create effective organisation of laboratories (equipment, reagents, workflow).

You…

  • Will join bit.bio as a keen team player driven by a passion for scientific discovery and cell biology.
  • Are a motivated experimentalist with scientific rigour and problem-solving attitude.

Essential for the role:

  • A Bachelor or Master’s degree in cell biology, neurobiology, molecular biology or similar, plus at least 1 year of laboratory experience in a R&D team in industry or academic research lab.
  • Practical experience of human pluripotent stem cells derived neuron / glia cell cultures.

… and desired experience…

  • With cell phenotypic characterisation (RT-qPCR, ICC).
  • Genetic modification techniques (transfection, transduction).
  • Functional assays of in vitro cultured neurons (e.g. MEA analysis).

 

You are welcome to apply

To be part of our dynamic, growing start-up team and share our vision to build together the leading cell coding company please send your CV and cover letter to careers@bit.bio

 

Manufacturing Development Research Assistant

Location: Babraham Research Campus, Cambridge
Type: Full time, permanent | Start: Immediate
Salary: Competitive | Hours: 40 p/w
Office Based Position

 

Your role in our team:

We are looking for an experienced member of the Manufacturing Development team to support the process development, scale-up and optimisation of GMP manufacture for a wide range of iPSC-derived cell types. You will work at the interface of R&D, providing technical and scientific expertise whilst devising robust manufacturing processes which will enable the translation of products from proof of principle to sterile manufacture. The Manufacturing Development Research Assistant will work closely with the R&D, Quality, Logistics and Commercial teams to help deliver a quality product to market. As such, there is a requirement to be diplomatic, collaborative, customer focused, change agile, comfortable in leading and adapting to changing priorities in a rapidly growing business.

 

Your key responsibilities will include:

  • Work collaboratively under the supervision of senior members of the team to develop manufacturing processes, SOPs and process transfer into GMP manufacture.
  • Support the delivery of manufacturing development projects by helping in their planning, execution and analysis of results. Including optimisation of key processes such as cryopreservation, establishment of QC criteria, running functional assays and in the design of experiments.
  • Assist in the benchmarking of products and support the Product Manager to meet product launch timelines.
  • Promote a proactive, continual improvement culture and systems to maintain high standards of service and good practice.
  • Proactively identify and determine current and future resource requirements – both people and systems – lead in the recruitment and establishment of both in a rapidly growing organisation.

You…

  • Have a degree in biological sciences / stem cell biology (or related field) with a minimum of 1-years experience in a relevant industry or scientific organisation.
  • Are process oriented and experienced in working to SOPs.
  • Are a motivated scientist demonstrating the highest scientific rigour, operational skill and work standards.
  • Are humble – sincere and secure – accepts own mistakes – prioritises team over personal goals.
  • Are hungry – driven and proactive – goes above and beyond the call of duty to achieve company results.
  • Are smart – astute and persuasive – uses emotional intelligence to lead and inspire colleagues.

With essential experience in:

  • Human induced pluripotent stem cell biology, characterisation and culture systems.
  • Cell phenotyping and functional end point analysis e.g. flow cytometry, qPCR, ICC, MEA analysis.
  • Excellent time management, organisation and communication skills.

… and possibly…

  • Expertise in continuous improvement (e.g. LEAN, 5S) and experience of working to a quality management system.
  • Have knowledge of cGMP processes & regulations applicable to human iPSCs.

 

You are welcome to apply

To be part of our dynamic, growing start-up team and share our vision to build together the leading cell coding company please send your CV and cover letter to careers@bit.bio

 

QMS Specialist

Location: Babraham Research Campus, Cambridge
Type: Full time, permanent | Start: Immediate
Salary: Competitive | Hours: 40 p/w
Office Based Position

 

Your role in our team:

  • Develop systems and establish procedures for documenting and monitoring processes such as non-conformities, change controls, deviations, Root Cause Analysis, CAPAs, internal and external audits, supplier approval, risk assessments, continuous improvement and signature register.
  • Lead change management such as non-conformities, change controls, deviations and CAPAs.
  • Ensure that the QA documentation and processes are current and in line with the relevant regulatory requirements.
  • Provide review, approval and QA Technical support to key business partners for the management of quality records e.g. risk assessments, continuous improvement, change controls, non-conformities, deviations, CAPAs, supplier approvals and Root Cause Analysis.
  • Implement, monitor and provide appropriate KPIs for the QA processes, escalate any trending observed to senior management.
  • Create, revise and maintain QA standard operating procedures (SOPs) and other documents as required.
  • Act as QA subject matter expert to support business requirements.
  • Ensure the internal audits are up to date with the 12 month plan and any actions are tracked, followed up and closed in a timely manner.
  • Provide direct Quality team support during customer audits and regulatory inspections.
  • Ensure any actions from customer audits and regulatory inspections are tracked, followed up internally and ensure responses are sent out to the customer/or regulatory bodies in a timely manner.
  • Provide direct support for quality related customer complaint investigations and trending activities and ensure responses are sent to the customer in a timely manner.
  • Provide Quality systems and process training across the business.
  • Provide Quality induction for all new employees, including refresher training.
  • Provide direct Quality team support during customer audits and regulatory inspections.
  • Manage the Archiving of business data, both paper based and electronic.
  • Manage the collation of data reporting of the Annual Product Reviews for approval.
  • Write, review and approve Quality Technical Agreements as and when required.

You…

  • Have a degree level or equivalent qualifications in a relevant discipline.
  • Are humble – sincere and secure – accepts own mistakes – prioritises team over personal goals.
  • Are hungry – driven and proactive – goes above and beyond the call of duty to achieve company results.
  • Are smart – astute and persuasive – uses emotional intelligence to assist and collaborate with colleagues.

With essential experience in…

  • Documentation Control within a cGMP environment.
  • Good Manufacturing Practice within a Pharmaceutical or related environment.
  • Good documentation Practice and principles of Data Integrity.
  • Knowledge and expertise in the QMS processes.
  • Proficient use of Excel, Word and PowerPoint.
  • Excellent time management, organisation, and communication skills.

… and possibly…

  • Experienced in working in a scientific / cell therapy environment.
  • Experienced in Continual Improvement Tools e.g. LEAN, 5S, Kanban, Kaizen, RCA, VSM.
  • QESH Management System / ISO9001 / PDCA Training.

 

You are welcome to apply

To be part of our dynamic, growing start-up team and share our vision to build together the leading cell coding company please send your CV and cover letter to careers@bit.bio

 

Business Intelligence & Reporting Lead

Location: Remote or Babraham Research Campus, Cambridge
Type: Full time, permanent | Start: Immediate
Salary: Competitive | Hours: 40 p/w

 

Your role in our team:

bit.bio has set off on a path to revolutionise drug discovery and cell therapy. We aspire to become a machine-learning company and be insights-driven right from the beginning, to support our strong growth trajectory and mission. The Business Intelligence and Reporting Lead position is being created to spearhead the achievement of this goal at an organisational level. In this role, we require someone with a penchant and instinct for insight generation encompassing every aspect of running an ambitious business with an exciting mission, and a deep experience in running Analytics programmes (platforms and operations).

 

Your key responsibilities will include:

  • Creating and operating a Reporting Infrastructure – lead the creation of management dashboards and visualisations on a diverse set of data pertaining to bit.bio business and operations.
  • Creating and operating a Business Intelligence/ Analytics function – setting up early work on insights generation from a wide variety of data of value from internal and external sources, and creating an ambitious roadmap for analytics.
  • Deploying and operating a Data Analytics platform – putting in place state-of-the-art data analytics infrastructure for integrating and analysing data to serve organisational needs for insights.
  • Building a Machine Learning capability and culture – be responsible for building a prediction-based decision-making culture, where we maximise the ability to use data to forecast the future, continuously learning from it; build a technology infrastructure that supports that culture fully.
  • Support Data Strategy development – provide inputs from a Business Intelligence and Reporting perspective on strategic principles, processes, data, tools and other capabilities required to create a robust data strategy for the organisation.
  • Support Data Standards and Policy development – provide inputs on data acquisition, management, retention and governance with a focus on analytics and reporting, to aid standards and policy development.
  • Support Communications development – provide data-driven stories and inputs to organisational communications’ efforts to make them interesting and insightful.

You have…

  • A deep interest in data as a resource, with instinct and passion for supporting missions that are insights-driven.
  • A proactive and collaborative problem-solving approach and a high level of initiative, along with good ability to organise yourself well at work.
  • An ability to construct and articulate insights-driven stories to a variety of audiences.
  • A Bachelors’ degree followed by a minimum of 10 years’ of relevant experience, in industries that are knowledge-driven, and in roles focused on insights’ development.
  • At least 8 years’ of deep experience in Databases, Reporting and Analytics, Data Integration, Analytics Platforms, Cloud, API design, leading teams and managing a variety of stakeholder expectations.

With demonstrable experience of success and knowledge in:

  • A variety of databases – for managing structured, semi-structured and unstructured information.
  • Requirements Analysis in a Reporting and/or Analytics capacity serving a variety of business functions (at least 3 out of Operations, Marketing, Finance, Manufacturing, Sales, Product Management).
  • Handling insights’ needs of a large department or a small-to-medium sized organisation.
  • Implementing end-to-end projects in Data Integration, Reporting, Analytics, Software Platform deployment, including activities of business case development, project and release management, and testing.
  • Analytics strategy and roadmap development.
  • Building effective analytics’ processes and governing them.
  • Deploying and using analytics tools and platforms (such as Qlik, Tableau, SAS, Microstrategy).
  • Cloud environments.
  • Designing and implementing APIs.
  • Working with a variety of stakeholders at all levels and shaping the thinking around creating insights and being insights-driven.
  • Managing multiple requests and priorities in a fast paced environment.
  • Written communication and presentations articulating complex ideas in simplified comprehensible form.

… and preferably

  • A good exposure and understanding of Machine Learning.
  • A Masters degree in a strong quantitative and/or informatics discipline.
  • A good exposure and understanding of Machine Learning.
  • AWS cloud services knowledge and exposure.
  • Designing and building APIs (RESTful, etc.).
  • Exposure to semantic data integration.

 

You are welcome to apply

To be part of our dynamic, growing start-up team and share our vision to build together the leading cell coding company please send your CV and cover letter to careers@bit.bio

 

Lead Business Analyst

Location: Remote or Babraham Research Campus, Cambridge
Type: Full time, permanent | Start: Immediate
Salary: Competitive | Hours: 40 p/w

Your role in our team:

bit.bio is growing rapidly. Our Operations, Science R&D and Commercial teams are having to set themselves up quickly to function in an integrated fashion – as one enterprise. This requires a large degree of automation and integration of core business processes, and new tools that will help accelerate our R&D and production of innovative products. To make this possible, we require a Lead Business Analyst to work closely with our Heads of departments and their nominated representatives to elicit, discover, validate, document, agree and present process automation and application/tool requirements to our IT/Software Engineering teams. The role will participate actively in testing custom-built and pre-packaged software to provide quality assurance, and carries the added responsibility of setting standards and coaching junior business analysts, acting as their functional lead.

    Your key responsibilities will include:

    • Liaising with Heads of our Operations, Science R&D and Commercial teams and their nominated representatives to understand and shape their process automation and application software/tool needs.
    • Creating business process flow diagrams that capture the context for automation to a high standard, turning them into reusable documentation that can be used as references for further projects.
    • Analysing tool and application requirements in detail, gathering detailed requirements and documenting them using prevalent requirements documentation standards (user stories/Behaviour-driven Development).
    • Developing business cases and contributing to creating/detailing project proposal forms with relevant information including risks/mitigation and effort/cost estimates, for Data infrastructure and IT application development/procurement projects.
    • Researching features of third-party applications and off-the-shelf software and software modules (such as ERP) and producing validation reports against stated requirements of internal stakeholders.
    • Guiding science-focused analysts, bioinformaticians and data engineers on optimal and fit-for-purpose ways of capturing requirements for data tool and algorithm development.
    • Developing a robust set of Business Analysis standards and leading their implementation and adoption.
    • Leading the knowledge transfer of Requirements to development teams.
    • Participating in Agile development sprints as acting Product Owner, maintaining user story and feature backlogs and actively collaborating with business/science stakeholders in prioritising user stories and tasks for upcoming sprints.
    • Leading sprint retrospectives and help business/science stakeholders identify improvements to be included in product backlogs and be considered for future sprints.
    • Leading by example in the adoption of Agile methodologies and participating in the set up of tools (such as JIRA) for management of requirements and the project process.
    • Working with testing teams and business stakeholders to provide Quality Assurance, actively contributing to test plans, scripts and product testing cycles.
    • Actively coach and mentor other Business Analysts in all of the above activities, monitor their progress and performance, and support their professional development.

    You will have:

    • A deep interest in Software Engineering, IT Application Management and the discipline of Business Analysis.
    • A passion to guide and coach other business analysts in the team to achieve a high degree of professionalism and quality in their work and output.
    • A proactive problem-solving approach and a high level of initiative, along with good ability to organise yourself well at work.
    • A Bachelors’ degree in Engineering, Computer Science or any other field that comes with a high degree of training in both structured analytical thinking and visual modeling of ideas.
    • An advanced Business Analysis certification from an industry-accredited body.
    • A minimum of eight years of overall experience in IT Business Analysis, and at least three years’ as a Lead Analyst.
    • At least five years of experience in each of the following:
      • Writing user stories and requirements documentation, using the Behaviour-driven Development method.
      • Working in an Agile environment in medium-sized to large companies, participating in sprints as the product owner and leading sprint retrospectives.
      • Product backlog management.
      • Writing business cases – including performing cost and effort estimations and risks/dependencies/issues analyses.
      • Visual modelling of processes (using Visio or a similar tool) and annotating them with information on inputs, outputs, data transformations and roles.
      • Working in a complex data-driven business environment.
      • Working in a Cloud environment for application and data deployment.
      • Working with analysis of core business processes and requirements for third-party Operations’ software, such as Financial and HR applications/ERP modules.
      • Working with a variety of stakeholders at all levels of the organisation.

    With essential experience and knowledge of:

    • Behaviour-driven development.
    • Behaviour-driven development.
    • Software testing/ Validation.
    • Software Engineering.
    • IT Application Management.
    • Agile methodologies and tools.
    • Business Analysis standards.

    … and possibly …

    • Exposure to scientific and research environments.
    • Exposure to scientific and research environments.
    • Exposure to highly regulated environments.
    • Exposure to IP generation from Process Automation and Software Engineering projects.


    You are welcome to apply

    To be part of our dynamic, growing start-up team and share our vision to build together the leading cell coding company please send your CV and cover letter to careers@bit.bio