Join the Bit Bio team

Cambridge Start Up of the Year 2018

Bit Bio is an award-winning spinout from the University of Cambridge. Our breakthrough technology combines synthetic and stem cell biology for the precise, efficient and consistent reprogramming of human cells used in research, drug discovery, and cell therapy. At Bit Bio, we are passionate about engineering human cells that will enable the medicine of the future. To do this we need talented and curious people who want to make an impact on the future of science and therapeutics.

As a team of individuals, we value science, collaboration, openness, curiosity and creativity. We are united by trust and respect for each other.

Bit Bio provides a vibrant and dynamic work environment in an exciting, fast-moving time for biology. We work with cutting edge technologies and with our world-leading scientific advisory board. We conduct pioneering work with real-world impact.

We trust our people to make significant contributions early on with opportunities to be involved in projects that are key to the success and growth of our young company. We invest in people, creating opportunities for personal development in an inclusive multi-skilled team with ambitious goals that provide opportunities to learn on the job from each other.

Creativity and open minds are encouraged for everyone to contribute to the success of the company.

To support Bit Bio staff and our culture further, we also offer a competitive salary, highly competitive benefits package including pension contribution scheme as well as health and life insurance.

To be part of our dynamic, growing start-up team and share our vision to build together the leading cell coding company, please send your CV and cover letter to careers@bit.bio

 

Head of Molecular Biology & Genetic Engineering

Location: Babraham Research Park, Cambridge
Type: Full time, permanent / Start: Immediate
Salary: Competitive / Hours: 40 p/w

Your role in our team:

We are looking for a highly experienced and established scientific leader with an outstanding track record to lead our molecular biology and genetic engineering endeavours. Reporting directly to our Chief Scientific Officer, the candidate will lead a team of scientists at a focal point within the wider R&D department. The main objectives of the team are:

  • To develop advanced, multiplexed gene editing approaches and high throughput genomic screens.
  • To conduct custom iPSC engineering.
  • To lead innovation and the development of novel reprogramming approaches.

Your key responsibilities will include:

  • Leading, inspiring and growing a team of scientists focussed on designing and executing innovative genome engineering strategies towards the generation of advanced human cells.
  • Contributing to the development of company strategic R&D programmes by advising on science and innovation in genetic engineering and synthetic biology.
  • Ensuring the management and delivery of multiple projects at the interface of key scientific programmes in consultation with lead scientists.
  • Working closely and collaboratively with our other Department Heads (Research, Bioinformatics and Machine Learning, Product management) to meet scientific and new product launch objectives.
  • Engaging with the academic and industry scientific community to promote and diversify the company R&D activities.

You:

  • Have a PhD in life sciences with a minimum of 5 year experience as a group leader in academia or industry.
  • Enjoy growing and leading a high-performing team of scientists (>7 direct reports).
  • Enjoy tackling research challenges through critical thinking and inventiveness, demonstrating the highest scientific rigour and work standards.
  • Are comfortable and used to working to tight timelines and managing workload and priorities.
  • Are keen to establish collaborations both inside and outside the company.
  • Are a passionate team player with excellent communication skills.

With essential experience:

  • Molecular biology and genetic engineering of mammalian cells.
  • High throughput genomic screens.
  • Team leadership and project management involving multiple internal and external stakeholders.

… and ideally …

  • Knowledge and hands on experience of human pluripotent stem cells.


You are welcome to apply

To be part of our dynamic, growing start-up team and share our vision to build together the leading cell coding company please send your CV and cover letter to careers@bit.bio

 

    Head of Pluripotent Stem Cell Platform

    Location: Babraham Research Park, Cambridge
    Type: Full time, permanent / Start: Immediate
    Salary: Competitive / Hours: 40 p/w

    Your role in our team:

    We are looking for an experienced scientific leader with excellent track record to develop our human pluripotent stem cell platform. Reporting directly to our Chief Scientific Officer, the candidate will lead a team of scientists at a focal point between the R&D and Cell Production departments. The main objectives of the team are:

    • To provide core scientific and material support to the R&D and Production teams in all activities related to human pluripotent stem cells (sourcing, characterisation, traceability and quality control, inventory management).
    • To lead innovation and strategic collaborations for the continuous development of the pluripotent stem cell core platform to accompany the company growth.

    Your key responsibilities will include:

    • Leading, inspiring and growing a team of dedicated scientists providing a state-of-the-art human pluripotent stem cell facility to support Bit Bio’s R&D and cell production capacity.
    • Operationally responsible for the running of the iPSC core facility.
    • Contributing to the development of company strategic programmes by driving innovation for human pluripotent stem cell culture.
    • Working in close collaboration with other Department Heads (Research, Clinical translation, Production and Product Management) to meet scientific, clinical and new product launch objectives.
    • Liaise with external bodies, collaborators and customers on any pluripotent stem cell related matters.
    • Engaging with the academic and industry scientific community to promote and diversify the company pluripotent stem cell activities.

    You:

    • Have a PhD in life sciences with a minimum of 5-years experience as a stem cell/cell line platform leader in a relevant industry or scientific organisation/institution.

    • Enjoy growing and leading a high-performing team of scientists.

    • Are process oriented and experienced in developing, optimising & implementing workflows, protocols, procedures and resources, with knowledge and experience in working in a quality management environment.

    • Enjoy tackling research challenges through critical thinking and inventiveness, demonstrating the highest scientific rigour, operational skills and work standards.

    • Are comfortable and used to working to tight timelines and managing workload and priorities.

    • Are a passionate team player with excellent communication skills.

    With essential experience:

    • Human pluripotent stem cell biology, characterisation and culture systems.
    • Team leadership and project management involving multiple internal and external stakeholders.
    • Working within a quality management environment.
    • Developing operational infrastructure.

    … and ideally …

    • Have knowledge of cGMP processes and regulations applicable to human iPSCs.
    • Cell culture and manufacture automation.
    • Genetic engineering.


    You are welcome to apply

    To be part of our dynamic, growing start-up team and share our vision to build together the leading cell coding company please send your CV and cover letter to careers@bit.bio

     

    Head of Quality

    Location: Babraham Research Park, Cambridge
    Type: Full time, permanent / Start: Immediate
    Salary: Competitive / Hours: 40 p/w

    Your role in our team:

    We are looking for an experienced Head of Quality to join our leadership team who uses their knowledge, expertise and influence to design, establish and deliver a comprehensive strategy for all quality functions at Bit Bio. Reporting to our Head of Research Operations, the successful candidate will oversee the strategic planning and implementation of an integrated Quality Management System across all aspects of the business, collaborating with other leaders to make final decisions and approvals on all quality-related policies, programs and initiatives. The successful candidate will interact with all levels of the business – internal and external – with a strong ability to negotiate and convince through clear communication and clarity, directing and controlling the activities of a broad functional area – and has overall control of planning, staffing, managing expense priorities, and recommending and implementing changes to policy and strategy. The primary aims of this role are to drive the quality strategy, institutionalise our quality appetite, champion organisational health whilst building a positive culture for the business (and specifically the future quality team). The candidate must be change agile, comfortable in leading and managing managers – with the flexibility to adapt in a rapidly growing cell coding company.

    Your key responsibilities will include:

    • Create and drive the quality strategy and champion processes to ensure operational efficiencies and effectiveness at organizational level.
    • Establish and sustain quality policies and procedures commensurate with the business context.
    • Evaluate and prioritise quality projects in line with the quality strategy.
    • Act as the company subject matter expert with regards to company, industry and governmental quality regulations.
    • Implement versatile management styles to lead and inspire managers across quality functions, including Quality Assurance, Quality Control and Regulatory.
    • Design the organization’s quality risk management and mitigation strategy, including a plan for continuity during periods of adverse events.
    • Develop a strong culture of openness based on colleague consultation, responsible decision taking and champion a practise of informed decision making.
    • Contribute actively, with other leadership team members, to communicate consistently the strategic anchors, core values and the company goals throughout the business and lead from the front in setting a style of team commitment.
    • Champion a culture of continual improvement (LEAN, 5S, Kanban, Kaizen, RCA, VSM) to the highest standards and practises.
    • Proactively identify resource gaps – recruit and develop the right talent required to build cohesive, functional quality teams.
    • Provide direction on the business risk and product quality appetite for balanced Quality Management Systems commensurate with business goals.
    • Lead internal/external audits towards accreditation to required standards (ISO/GMP/MHRA/FDA).

    You:

    • Have a degree in a relevant discipline (E).
    • Are humble – sincere and secure – accept own mistakes – prioritise team over personal goals.
    • Are hungry – driven and proactive – go above and beyond the call of duty to achieve company results.
    • Smart – astute and persuasive – use emotional intelligence to lead and inspire colleagues.

    With essential experience:

    • Leading both QA and QC functions (E).
    • Developing QMS (E) from scratch (D).
    • Working within highly regulated environments (GMP, ISO9001, ISO13485) (E).
    • Leading Quality managers and teams to a high degree of success (E).

    … and possibly …

    • Experienced in working within a cell culture / cell therapy environment (D).
    • A passion for continual improvement techniques (CAPA, RCA, LEAN, Six Sigma, 5S) (D).
    • Excellent organisational skills (D).
    • Excellent verbal and written communication skills (D).


    You are welcome to apply

    To be part of our dynamic, growing start-up team and share our vision to build together the leading cell coding company please send your CV and cover letter to careers@bit.bio

     

    Senior Scientist – Computational Biology (Single Cell Sequencing)

    Location: Babraham Research Park, Cambridge
    Type: Full time, permanent / Start: Immediate
    Salary: Competitive / Hours: 40 p/w

    Your role in our team:

    To execute and lead our ambitious research programmes for uncovering core transcription factor programs that define human cell types, we are looking for highly motivated and skilled senior scientists to join our growing team. You will become a key player in the delivery of strategic research projects, involved in their design, the analysis of experimental data and subsequent planning of further scientific development. You will be supervising junior and assistant scientists work towards project completion. This is an opportunity to join one of the best stem cell reprogramming labs and conduct research with a real-world impact.

    Your key responsibilities will include:

    • Delivering multidisciplinary research programmes contributing to the design and analysis of data from experimental projects.
    • Develop and maintain internal software, including the creation of well documented user-friendly tools.
    • Working collaboratively with experimental and computational biologists and leading projects including supervision of junior and assistant scientists.
    • Developing new research ideas with the scientific, business and leadership teams.
    • Contributing to strategic collaborations with key opinion leaders.
    • Providing technical and scientific expertise by contributing to proposals, meetings, publications and business development activities.
    • Disseminating Bit Bio’s vision and research to external scientific and lay audiences.

    You:

    • Will join Bit Bio as a keen team player driven by a passion for scientific discovery and cell biology.

    • Enjoy tackling research challenges through critical thinking, scientific rigour and inventiveness.

    • Are comfortable working to tight timelines and managing workload and priorities.

    • Your practical research experience and excellent organisational skills will allow you to work independently, provide leadership on project execution, be productive and output driven whilst building efficient and positive collaborations with the wider team.

    With essential experience:

    • A minimum of 3 years of post-doctoral experience in an area relevant to computational biology and genomics, and at least 3 years of experience doing primarily single cell RNA-seq analysis (can include time in PhD), with good knowledge of strengths, weaknesses, and caveats.
    • Proficiency in R and/or python and relevant packages.
    • Experience analyzing large datasets, including next-generation sequencing data, with high-performance computing clusters.
    • Strong biological knowledge and interest, and familiarity with major biological data resources.

    … and possibly …

    • Experience with Github and AWS.
    • Strong computational fundamentals including machine learning, algorithms, statistical methods, and data structures.
    • Familiarity with gene regulatory networks, mechanisms of gene expression, and developmental biology.
    • Experience with cell hashing, bulk RNA-seq, microarrays, ChIP-seq, ATAC-seq, and/or other genomic technologies.
    • Experience in industry.


    You are welcome to apply

    To be part of our dynamic, growing start-up team and share our vision to build together the leading cell coding company please send your CV and cover letter to careers@bit.bio

     

    Laboratory Manager

    Location: Babraham Research Park, Cambridge
    Type: Full time, permanent / Start: Immediate
    Salary: Competitive / Hours: 40 p/w

    Your role in our team:

    We are looking for an experienced Laboratory Manager to promote a proactive, continual improvement culture and to create and embed systems to maintain high standards of service and good lab practices. Reporting to our Head of Research Operations, the candidate will lead a team of up to three Laboratory Technicians at a focal point of ensuring effective laboratory operations while maintaining high levels of safety, quality and service. The primary aim of this role is to ensure laboratory space, equipment and consumables – used for the maintenance and differentiation of human induced Pluripotent Stem Cells – are kept clean, in safe, working condition and adequately stocked to maximise productivity and minimise delays for both Production and Research Scientists.

      Your key responsibilities will include:

      • Ensure the laboratory environment meets all regulatory, QEHS policies and procedures such that employees, visitors and the environment are protected from significant risk. This includes identifying, reporting and correcting QEHS deviations/failures as they occur.
      • Identify training gaps, coordinate and perform laboratory QEHS and equipment training.
      • Ensure all equipment/instrumentation is properly maintained and serviced complying with regulatory standards and ensure proper performance and function.
      • Establish strong relationships with the laboratory teams in order to understand and support their workload, challenges and constraints.
      • Implement industry best practice (e.g. LEAN, 5S, Kanban) to ensure the laboratory is adequately stocked with consumables, reagents and in-house aliquots in a clearly organised and accessible manner. This includes receiving all deliveries and organising their storage.
      • Implement systems to manage emergency situations within the laboratory, such as out-of-hours critical equipment breakdowns.
      • Author documented SOPs, where this is beneficial, for training and consistency in collaboration with QA and in line with the QEHS Management Systems.

      You:

      • Have a degree in a relevant scientific/process discipline.
      • Have excellent organisational skills.
      • Are driven and proactive and go above and beyond the call of duty.
      • Are confident, secure and open about own weaknesses.
      • Carry excellent interpersonal and communication skills.
      • Have the ability to lead and mentor others.
      • Are accurate, with a good attention to detail and aseptic technique.
      • Have mechanical prowess and equipment maintenance skills.

      With essential experience:

      • LEAN (5S, Kanban, Kaizen) Management.
      • Laboratory and People Management.
      • Training others to high degree of competence.
      • Working within research laboratory environment.
      • GMP/GLP principles.

      … and possibly …

      • LEAN Management Level 2 Certificate.
      • GLP/GMP Training certifications.
      • NEBOSH National Certificate in Occupational Health and Safety.
      • QESH / ISO9001 Training.


      You are welcome to apply

      To be part of our dynamic, growing start-up team and share our vision to build together the leading cell coding company please send your CV and cover letter to careers@bit.bio

       

        Research Project Manager

        Location: Babraham Research Park, Cambridge
        Type: Full time, permanent / Start: Immediate
        Salary: Competitive / Hours: 40 p/w

        Your role in our team:

        We are looking for an experienced Project Manager who uses their knowledge, expertise and influence to coordinate and deliver all research projects assigned to them, on time and within budget, in accordance with company objectives and key results. The successful candidate will be responsible for supporting multiple research projects undertaken within a CRISPR gene-editing, cell reprogramming and iPSC derived, human cell research environment. The primary aim of this role is to provide a project management service to the research scientists, required for the successful and timely completion of projects and associated experiments taking place in the laboratory. The candidate must be diplomatic, collaborative, and internal customer-focused – where the customers are the research scientists. There is a requirement to be change agile, comfortable in leading and adapting to changing priorities in a rapidly growing business.

          Your key responsibilities will include:

          • Planning, execution, monitoring, coordination and control of research projects to completion.
          • Managing the day-to-day project tasks and workflow.
          • Execute strategy for ensuring success of new and on-going projects within agreed timelines, budget, scope and internal customer expectations.
          • Ensure all necessary resources are identified and available.
          • Lead regular project meetings with internal customers and stakeholders.
          • Communicate timely project updates and progress to internal customers and stakeholders.
          • Use a mix of creative and established tools to manage and communicate effectively.
          • Plan project timelines, project tasks and follow projects their entire lifecycle.
          • Identify, manage and mitigate project risks and obstacles.
          • Manage changes in project scope, timelines, and priorities.

          You:

          • Have a degree in a relevant scientific/process discipline.
          • Are a qualified Agile, Prince 2, PMP practitioner – or have equivalent experience in Project Management methodologies.
          • Have excellent organisational skills.
          • Are driven and proactive and go above and beyond the call of duty.
          • Are confident, secure and open about own weaknesses.
          • Carry excellent interpersonal and communication skills.

          With essential experience:

          • Project management principles and project life-cycle methodologies.
          • Completing successful projects, in the life science sector.
          • Presenting complex ideas to a variety of audiences.

          … and possibly …

          • Experienced in Continual Improvement Tools e.g. LEAN, 5S, Kanban, Kaizen, RCA, VSM.
          • LEAN Management / LEAN Six Sigma Certification.
          • QESH Management System / ISO9001 / PDCA Training.
          • Training in GMP/GLP principles.
          • Working in a research laboratory environment


          You are welcome to apply

          To be part of our dynamic, growing start-up team and share our vision to build together the leading cell coding company please send your CV and cover letter to careers@bit.bio

           

            Research Assistant – Cell Biology (Neuroscience)

            Location: Babraham Research Park, Cambridge
            Type: Full time, permanent / Start: Immediate
            Salary: Competitive / Hours: 40 p/w

            Your role in our team:

            To support the execution of our ambitious research programmes for generating human cell type diversity by cellular reprogramming, we are looking for motivated and skilled assistant scientists to join our growing science team as part of our neuroscience programme. You will become a key player in the delivery of strategic research activities, being involved in the design, execution and reporting of experimental work. This is an opportunity to join one of the best stem cell reprogramming labs and conduct research with a real-world impact.

              Your key responsibilities will include:

              • Working collaboratively with the wider team under supervision of senior scientists.

              • Design and execution of experiments, analysis and reporting of results.

              • Providing technical and scientific expertise to the R&D team by contributing to protocol development and diffusion.

              • Working with the wider team to create effective organisation of laboratories (equipment, reagents, workflow).

              You:

              • Will join Bit Bio as a keen team player driven by a passion for scientific discovery and cell biology.

              • Are a motivated experimentalist with scientific rigour and problem-solving attitude.

              With essential experience:

              • A Bachelor or Master’s degree in cell biology, neurobiology, molecular biology or similar, plus at least 1 year of laboratory experience in a R&D team in industry or an academic research lab.

              • Practical experience of human pluripotent stem cells derived neuron cultures.

              And desired experience:

              • With cell phenotypic characterisation (RT-qPCR, ICC).

              • Genetic modification techniques (transfection, transduction).

              • And functional assays of in vitro cultured neurons (e.g. MEA analysis).


              You are welcome to apply

              To be part of our dynamic, growing start-up team and share our vision to build together the leading cell coding company please send your CV and cover letter to careers@bit.bio

               

                Research Assistant – Molecular Biology

                Location: Babraham Research Park, Cambridge
                Type: Full time, permanent / Start: Immediate
                Salary: Competitive / Hours: 40 p/w

                Your role in our team:

                To support the execution of our ambitious research programmes for generating human cell type diversity by cellular reprogramming, we are looking for motivated and skilled assistant scientists to join our growing science team. You will become a key player in the delivery of strategic research programmes, being involved in the design, execution and reporting of experimental work. This is an opportunity to join one of the best stem cell reprogramming labs and conduct research with a real-world impact.

                  Your key responsibilities will include:

                  • Working collaboratively with the wider team under supervision of senior scientists.
                  • Design and execution of experiments, analysis and reporting of results.
                  • Providing technical and scientific expertise to the R&D team by contributing to protocol development and diffusion.
                  • Working with the wider team to create effective organisation of laboratories (equipment, reagents, workflow).

                  You:

                  • Will join Bit Bio as a keen team player driven by a passion for scientific discovery and cellbiology.
                  • Are a motivated experimentalist with scientific rigour and problem-solving attitude.

                  With essential experience:

                  • A Bachelor or Master’s degree in cell biology, molecular biology or similar, plus at least 1 year of laboratory experience in a R&D team in industry or an academic research lab.
                  • Practical experience of mammalian tissue culture, basic cell phenotyping and molecular biology techniques.
                  • Experience performing CRISPR genome editing experiments (knock-out, knock-in, clonal selection and genotyping).

                  And desired experience:

                  • With human pluripotent stem cell culture.
                  • Laboratory automation using liquid handling robots.


                  You are welcome to apply

                  To be part of our dynamic, growing start-up team and share our vision to build together the leading cell coding company please send your CV and cover letter to careers@bit.bio