German Stem Cell Network
The conference will cover the latest findings in stem cell biology with international keynotes, lots of presentations from selected abstracts, a Presidential Symposium with GSCN Awardees, a non-PI Meeting, and an ELSA Symposium.
The conference will cover the latest findings in stem cell biology with international keynotes, lots of presentations from selected abstracts, a Presidential Symposium with GSCN Awardees, a non-PI Meeting, and an ELSA Symposium.
We are sponsors at this event!
Come and visit our team at our booth #7 and meet our team to discuss how bit.bio offers partnering opportunities that affords access to the most relevant parental human cell types and corresponding disease models. These models are physiologically relevant and highly characterised, offering predictive, in vitro, human cells for early drug discovery, phenotypic screening, and high-content imaging applications.
Rebecca Northeast | Senior Product Manager | bit.bio will be speaking on 'Harnessing CRISPR-Ready human iPSC derived cells for disease modelling and drug discovery in neurodegenerative diseases. In this talk, we present a solution with CRISPR-Ready ioCells, specifically ioGlutamatergic Neurons and ioMicroglia engineered with constitutive expression of cas9, built for the routine generation of genetic knockouts and CRISPR screening workflows. We performed a scCRISPR screen in these cells, revealing disease-associated genes whose knockout caused significantly altered transcriptomic signatures. In ioMicroglia, the same scCRISPR screening workflow highlighted genes that influenced the response to LPS stimulation, shedding light on microglial activation dynamics. Taken together, CRISPR-Ready ioCells provide a unique platform for comprehensive exploration of disease-relevant cell states, laying the foundation for advanced disease modelling, target discovery, and validation.