Genetic content of adult somatic cells tested by nuclear transplantation from cultured cells
R. A. Laskey, J. B. Gurdon. 1970. Nature
It has yet to be proved that somatic cells of an adult animal possess genes other than those necessary for their own growth and differentiation. A particularly stringent test of the genetic content of the nucleus of a somatic cell is provided by transplanting it to an enucleated egg. The development of the egg tests the capacity of the genes in the transplanted nucleus to elicit normal early development and differentiation. Although this method has been applied to certain cells of embryos, larvae1,2, and newly metamorphosed froglets3, it has not been possible, until now, to transfer nuclei successfully from the cells of normal adult animals.
Nature 1970 https://www.nature.com/articles/2281332a0
Bits of bio by Kaiser Karim
Kaiser Karim, Senior Scientist at bit.bio, presenting seminal paper: Genetic content of adult somatic cells tested by nuclear
transplantation from cultured cells (R. A. Laskey, J. B. Gurdon)