Genotype and phenotype validation of an isogenic human iPSC-derived neuronal model of Huntington’s Disease

This scientific poster shows data validating both the genotype and phenotype of these cells, including gene and protein expression profiles, and electrophysiological analysis in comparison to an isogenic control.

You will explore:

• How ioGlutamatergic Neurons HTT 50CAG/WT were generated using opti-ox precision cellular reprogramming and CRISPR-Cas9 genome engineering
• Data describing the genotype and phenotype of these cells, including RT-qPCR, ICC, Bulk-RNA seq and MEA, all in comparison to an isogenic control
• How ioGlutamatergic Neurons HTT 50CAG/WT form a powerful next-generation model to study Huntington’s disease in research and drug discovery