Webinar

Human iPSC-Based Models of Glial Cells for Studying Neurodegenerative Disease

This webinar explores the increasing implication of glial cells in neurodegenerative diseases making them an appealing addition to iPSC-based model systems for investigating disease mechanisms. Over the last decade, Dr. Fossati’s lab has developed robust and efficient protocols to generate human oligodendrocytes, astrocytes, microglia, neurons, and complex 3D organoid cultures with the full compendium of glia and neuronal cells. Investigating the crosstalk between neurons and glia allows for identification and targeting of glial-driven pathogenic mechanisms linked to neuroinflammation and neurodegeneration.
Human iPSC-Based Models of Glial Cells for Studying Neurodegenerative Disease

Valentina Fossati, PhD

Senior Research Investigator

The New York Stem Cell Foundation

Human iPSC-Based Models of Glial Cells for Studying Neurodegenerative Disease

Inês Ferreira

Senior Product Manager

bit.bio

Human iPSC-Based Models of Glial Cells for Studying Neurodegenerative Disease
This webinar explores the increasing implication of glial cells in neurodegenerative diseases making them an appealing addition to iPSC-based model systems for investigating disease mechanisms. Over the last decade, Dr. Fossati’s lab has developed robust and efficient protocols to generate human oligodendrocytes, astrocytes, microglia, neurons, and complex 3D organoid cultures with the full compendium of glia and neuronal cells. Investigating the crosstalk between neurons and glia allows for identification and targeting of glial-driven pathogenic mechanisms linked to neuroinflammation and neurodegeneration.
Human iPSC-Based Models of Glial Cells for Studying Neurodegenerative Disease

Valentina Fossati, PhD

Senior Research Investigator

The New York Stem Cell Foundation

Human iPSC-Based Models of Glial Cells for Studying Neurodegenerative Disease

Inês Ferreira

Senior Product Manager

bit.bio

As neurodegenerative diseases continue to impact millions, researchers are increasingly exploring the role of glial cells in CNS health and disease. Could specific glial cell behaviours drive the progression of diseases like multiple sclerosis or Alzheimer’s? 

Watch this insightful webinar featuring Dr. Valentina Fossati, Senior Research Investigator at the New York Stem Cell Foundation, and Inês Ferreira, Senior Product Manager at bit.bio.

Dr. Fossati will highlight how adding glial cells into human iPSC-derived models contributes to our understanding of disease mechanisms.

Inês Ferreira will share findings from a collaboration with Charles River Laboratories, focusing on complex models utilising ioOligodendrocyte-like cells, ioMicroglia, and ioGlutamatergic Neurons to study neuroinflammation and neurodegeneration.

Key learning points: 

  • Discover the critical roles of glial cells in CNS diseases
  • Learn about methods for developing human glial cell models
  • Explore how human models reveal intrinsic phenotypes of multiple sclerosis
  • Learn how ioCells can be used in complex cell models to study neurodegeneration

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