Modelling Alzheimer's disease with human iPSC-derived cells

Consistent, defined and scalable human iPSC-derived disease models for Alzheimer's disease research and drug discovery

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Alzheimer's disease, the most common type of dementia, is a neurodegenerative disorder that progressively undermines patients' cognitive abilities, impairing their capacity to create and retrieve memories. Studying Alzheimer’s disease remains a significant challenge, in part because of difficulties accurately emulating the disease's pathophysiology in vitro.

There is a pressing need for an in vitro model of Alzheimer's disease that can be used to accurately and reliably study the effect of disease-associated mutations, disease progression and to identify potential therapeutic targets. ioDisease Model Cells provide scientists with defined, consistent and scalable human iPSC-derived cells engineered with common monogenic Alzheimer’s disease-related mutations, helping improve the translatability of in vitro research. 

Discover ioDisease Model Cells for modelling Alzheimer’s disease in vitro below.

Alzheimer's disease models in ioMicroglia

ioMicroglia TREM2 R47H/WT ioDisease Model Cells
ioMicroglia TREM2 R47H/WT cat no | io1038
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ioMicroglia TREM2 R47H/R47H ioDisease Model Cells
ioMicroglia TREM2 R47H/R47H cat no | io1035 | io1036
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ioMicroglia APOE 4/3 C112R/WT ioDisease Model Cells
ioMicroglia APOE 4/3 C112R/WT cat no | io1033 | io1034
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ioMicroglia APOE 4/4 C112R/C112R ioDisease Model Cells
ioMicroglia APOE 4/4 C112R/C112R cat no | io1031 | io1032
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Alzheimer's disease models in ioGlutamatergic Neurons

ioGlutamatergic Neurons APP V717I/V717I ioDisease Model Cells
ioGlutamatergic Neurons APP V717I/V717I cat no | io1063
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ioGlutamatergic Neurons APP V717I/WT ioDisease Model Cells
ioGlutamatergic Neurons APP V717I/WT cat no | io1067
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ioGlutamatergic Neurons APP KM670/671NL/WT ioDisease Model Cells
ioGlutamatergic Neurons APP KM670/671NL/WT cat no | io1061
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ioGlutamatergic Neurons APP KM670/671NL / KM670/671NL ioDisease Model Cells
ioGlutamatergic Neurons APP KM670/671NL / KM670/671NL cat no | io1059
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ioGlutamatergic Neurons PSEN1 M146L/M146L ioDisease Model Cells
ioGlutamatergic Neurons PSEN1 M146L/M146L cat no | io1069
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ioGlutamatergic Neurons PSEN1 M146L/WT ioDisease Model Cells
ioGlutamatergic Neurons PSEN1 M146L/WT cat no | io1072
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Alzheimer's disease models in ioGABAergic Neurons

ioGABAergic Neurons APP V717I/WT ioDisease Model Cells
ioGABAergic Neurons APP V717I/WT cat no | io1084 | io1085
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ioGABAergic Neurons APP V717I/V717I ioDisease Model Cells
ioGABAergic Neurons APP V717I/V717I cat no | io1081 | io1082
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Pair ioDisease Model Cells with a genetically matched control

ioMicroglia | Female ioWild Type Cells
ioMicroglia | Female cat no | io1029
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ioMicroglia | Male ioWild Type Cells
ioMicroglia | Male cat no | io1021
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ioGlutamatergic Neurons ioWild Type Cells
ioGlutamatergic Neurons cat no | io1001
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ioGABAergic Neurons ioWild Type Cells
ioGABAergic Neurons cat no | io1003
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Generate your own Alzheimer's disease-related gene knockouts with ioCRISPR-Ready Cells 

Generate any knockout mutation related to Alzheimer's disease with ioCRISPR-Ready Cells. These cells have Cas9 constitutively expressed, enabling scientists to easily knockout their gene of interest in physiologically relevant cells in a matter of days.

Discover ioCRISPR-Ready Cells
ioGlutamatergic-Neurons-CRISPR-Ready-Hero-Image square

Don’t see what you’re looking for? Partner with us to generate custom ioDisease Model Cells to study Alzheimer's disease

Access our platform to generate custom ioCells to precisely answer your drug discovery and disease research questions.

Learn more about our custom ioDisease Model Cells offering
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Related pages

Discover ioCells Learn about our range of human iPSC-derived cells for research and drug discovery
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