cat no | io1069
ioGlutamatergic Neurons PSEN1 M146L/M146L
Human iPSC-derived Alzheimer's disease model
A rapidly maturing, physiologically relevant, functional system for investigating the role of the homozygous PSEN1 M146L mutation in early-onset Alzheimer's disease (AD). This in vitro disease cell model recapitulates an increase in the amyloid beta peptide ratios observed in AD patients.
ioGlutamatergic Neurons PSEN1 M146L/M146L are opti‑ox deterministically programmed glutamatergic neurons carrying a genetically engineered homozygous M146L mutation in the PSEN1 gene encoding presenilin 1 protein.
Place your order
Confidently investigate your phenotype of interest across multiple clones with our disease model clone panel. Detailed characterisation data (below) and bulk RNA sequencing data (upon request) help you select specific clones if required.
Benchtop benefits
Disease-related phenotype
Increased ratio of A𝛽42:40 and A𝛽42:38 peptides compared to the genetically matched control, measured by immunoassay.
Make True Comparisons
Pair the Alzheimer's disease model cells with the genetically matched wild-type ioGlutamatergic Neurons to investigate the impact of the PSEN1 missense mutation on early-onset AD.
Quick
The disease model cells and wild-type control are experiment ready as early as 2 days post revival, and form structural neuronal networks at 11 days.
Disease-related phenotype
PSEN1 M146L disease models recapitulate an increase in amyloid beta peptide ratios observed in Alzheimer's disease patients
ioGlutamatergic Neurons PSEN1 M146L disease model cells show an increase in the ratio of A𝛽42:40 and A𝛽42:38 compared to the wild type, genetically matched control.
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ioGlutamatergic Neurons wild type (WT) and PSEN1 M146L heterozygous (HET) clones CL8 (io1072S), CL60 and CL57, and homozygous (HOM) clones CL15 (io1069S), CL19 and CL57, were seeded at 30,000 cells/cm2 in 24-well plates and cultured for 30 days according to the user manual. Supernatant was collected at days 10, 20, and 30; data shown for day 30 only.
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Levels of A𝛽38, A𝛽40 and A𝛽42 peptides were quantified using the V-PLEX A𝛽 Peptide Panel 1 (6E10) Kit (MSD K15200E-1). Data were obtained from two independent experiments and are shown as mean ± SEM. Data were analysed statistically using one-way ANOVA with Tukey’s post-hoc analysis. * p<0.05 ***p<0.001 **** p<0.0001.
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Expression levels for specific genes of interest in the disease model products io1072 (CL8, het) and io1069 (CL15, hom) and the additional clones (CL60, CL71, CL19, CL57) can be requested by contacting technical@bit.bio
Highly characterised and defined
ioGlutamatergic Neurons PSEN1 M146L/M146L express neuron-specific markers comparably to the wild type control
Immunofluorescent staining on post-revival day 11 demonstrates similar homogenous expression of pan-neuronal proteins MAP2 and TUBB3 (upper panel) and glutamatergic neuron-specific transporter VGLUT2 (lower panel) in ioGlutamatergic Neurons PSEN1 M146L/M146L compared to the genetically matched control. 100X magnification.
ioGlutamatergic Neurons PSEN1 M146L/M146L form structural neuronal networks by day 11
ioGlutamatergic Neurons PSEN1 M146L/M146L mature rapidly, show glutamatergic neuron morphology and form structural neuronal networks over 11 days, highly similar to the genetically matched control. Day 1 to 11 post thaw; 100X magnification.
ioGlutamatergic Neurons PSEN1 M146L/M146L demonstrate gene expression of neuronal-specific and glutamatergic-specific markers following deterministic programming
Gene expression analysis demonstrates that ioGlutamatergic Neurons PSEN1 M146L/M146L and wild-type ioGlutamatergic Neurons (WT Control) lack the expression of pluripotency markers (NANOG and OCT4) at day 11, whilst robustly expressing pan-neuronal (TUBB3 and SYP) and glutamatergic-specific (VGLUT1 and VGLUT2) markers, as well as the glutamate receptor GRIA4. Gene expression levels were assessed by RT-qPCR (data normalised to HMBS; cDNA samples of the parental human iPSC line (hiPSC) were included as reference). Data represents day 11 post-revival samples, n=2 replicates.
Disease-related PSEN1 is expressed in ioGlutamatergic Neurons PSEN1 M146L/M146L following deterministic programming
RT-qPCR analysis demonstrates a similar expression level of the PSEN1 gene in both wild type ioGlutamatergic Neurons (WT Control) and ioGlutamatergic Neurons PSEN1 M146L/M146L at day 11 post-revival. Data normalised to HMBS, n=2 replicates.
Cells arrive ready to plate
ioGlutamatergic Neurons PSEN1 M146L/M146L are delivered in a cryopreserved format and are programmed to mature rapidly upon revival in the recommended media. The protocol for the generation of these cells is a two-phase process: Phase 1, Stabilisation for 4 days; Phase 2, Maintenance, during which the neurons mature. Phases 1 and 2 after revival of cells are carried out by the customer.
Industry leading seeding density
The recommended minimum seeding density is 30,000 cells/cm2, compared to up to 250,000 cells/cm2 for other similar products on the market. One small vial can plate a minimum of 0.7 x 24-well plate, 1 x 96-well plate, or 1.5 x 384-well plates. This means every vial goes further, enabling more experimental conditions and more repeats, resulting in more confidence in the data.
(LinkedValues: [{hs_name=Developing next-generation in vitro phenotypic assays for Huntington’s disease by combining a precision reprogrammed hiPSC-derived disease model with high-density microelectrode arrays, hs_id=161727133271, hs_path=ioglutamatergic-neurons-htt-maxwell-crl, button_label=null, button_link=null, type={label=Application note, value=Application note}, thumbnail={alt_text=, width=600, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Product%20pages/ioGlutamatergic%20Neurons%20HTT%2050CAGWT/a-HTT50CAGWT_Overlay__TUBB3(G)_MAP2(R)_DAPI(B)_%20(1).png, height=378}, year={label=2022, value=2022}, summary=<p>bit.bio | MaxWell Biosystems | Charles River Laboratories</p>
<p>2022</p>, date_published=1708560000000, sort_date=1668556800000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}, {label=ioGlutamatergic Neurons HTT 50CAG/WT, value=ioGlutamatergic Neurons HTT 50CAG/WT}], media_contact=<p>bit.bio | MaxWell Biosystems | Charles River Laboratories</p>
<p>2022</p>
<p> </p>, listing_button_label=Download}, {hs_name=Sartorius application note - Advanced in vitro Modeling of Human iPSC-derived Neuronal Mono- and Co-cultures with Microglia, hs_id=177620758074, hs_path=sartorius-application-note-advanced-in-vitro-modeling-of-human-ipsc-derived-neuronal-mono-and-co-cultures-with-microglia, button_label=null, button_link=null, type={label=Application note, value=Application note}, thumbnail={alt_text=co culture low density progenitors compressed, width=1732, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Product%20pages/ioMicroglia/co%20culture%20low%20density%20progenitors%20compressed.png, height=970}, year={label=2024, value=2024}, summary=Trigg et al.,<br>Sartorius<br>2024, date_published=1725580800000, sort_date=1725580800000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}, {label=ioMicroglia, value=ioMicroglia}, {label=ioGlutamatergic Neurons HTT 50CAG/WT, value=ioGlutamatergic Neurons HTT 50CAG/WT}], media_contact=Trigg et al.,<br>Sartorius<br>2024, listing_button_label=Download}, {hs_name=Producing 3D Neuronal Microtissues for Preclinical Drug Screening using ioGlutamatergic Neurons, hs_id=180505546901, hs_path=glutamatergic-neuron-3d-neuronal-microtissues-inventia, button_label=null, button_link=null, type={label=Application note, value=Application note}, thumbnail={alt_text=bitbio-ioGlutamatergic-Neurons, width=1700, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Product%20pages/ioGlutamatergic%20Neurons/bitbio-ioGlutamatergic-Neurons.jpg, height=1300}, year={label=2024, value=2024}, summary=V1<br>2024<br>bit.bio<br>Inventia, date_published=1728345600000, sort_date=1728345600000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}, {label=ioAstrocytes, value=ioastrocytes}], media_contact=V1<br>2024<br>bit.bio<br>Inventia, listing_button_label=Download}, {hs_name=Generating publishable neuroscience research in 12 weeks with ioGlutamatergic Neurons, hs_id=161746296926, hs_path=generating-publishable-neuroscience-research-in-12-weeks-with-glutamatergic-neurons, button_label=null, button_link=null, type={label=Case study, value=Case study}, thumbnail={alt_text=, width=2400, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Compressed%20Photos%20and%20Gifs/bit.bio_case_study_Pic0012_WebRes.jpg, height=1600}, year={label=2024, value=2024}, summary=<p>Professor Deepak Srivastava</p>
<p>Professor of Molecular Neuroscience and Group Leader, MRC Centre for Developmental Disorders</p>
<p>King’s College London </p>, date_published=1710720000000, sort_date=1705276800000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}], media_contact=<p>V2</p>
<p>2024</p>
<p>bit.bio</p>, listing_button_label=Download}, {hs_name=ioGlutamatergic Neurons , hs_id=161746296923, hs_path=glutamatergic-neurons, button_label=View brochure, button_link=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Resources/Brochures/bit.bio-ioGlutamatergic%20Neurons-Brochure.pdf, type={label=Brochure, value=Brochure}, thumbnail={alt_text=, width=2550, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Discover%20ioCells/iowild-type/bit.bio-ioGlutamatergic-Neurons-Day-14-Beta-III-Tubulin-staining-banner.jpg, height=1791}, year={label=2024, value=2024}, summary=<p>bit.bio</p>, date_published=1713312000000, sort_date=1713312000000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}, {label=ioAstrocytes, value=ioAstrocytes}, {label=Product information, value=Product information}], media_contact=null, listing_button_label=Download}, {hs_name=High Content Analysis of 2D and 3D cellular models for target and phenotypic drug discovery, hs_id=161961134487, hs_path=charles-river-poster-high-content-analysis-of-cellular-models, button_label=View poster, button_link=https://bit.bio/hubfs/BitBio_April2021/pdf%20link/2020_Lachize-et-al_High-Content-Analysis-of-2D-and-3D-Cellular-Models_Charles-River.pdf, type={label=Poster, value=Poster}, thumbnail={alt_text=, width=1700, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Product%20pages/ioGlutamatergic%20Neurons/bitbio-ioGlutamatergic-Neurons.jpg, height=1300}, year={label=2020, value=2020}, summary=<p>Lachize, et al</p>
<p>Courtesy of Charles River Laboratories</p>
<p>2020</p>, date_published=1706313600000, sort_date=1602806400000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}], media_contact=null, listing_button_label=View}, {hs_name=Development and characterisation of a robust in vitro disease model to study tauopathies, hs_id=161961134488, hs_path=ftd-mapt-phenotype-poster-charles-river-mar23, button_label=View poster, button_link=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Resources/SFN2022-Development-and-characterization-of-a-robust-in-vitro-disease-model-to-study-tauopathies.pdf, type={label=Poster, value=Poster}, thumbnail={alt_text=, width=1000, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Product%20pages/MAPT%20P301S/MAPT%20P301SP301S%20final%20homepage%20image.jpg, height=1400}, year={label=2022, value=2022}, summary=<p>Ritsma, et al</p>
<p>Charles River Laboratories & bit.bio</p>
<p>2022</p>, date_published=1708646400000, sort_date=1678924800000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}, {label=ioGlutamatergic Neurons MAPT P301S/WT, value=ioGlutamatergic Neurons MAPT P301S/WT}, {label=ioGlutamatergic Neurons MAPT P301S/P301S, value=ioGlutamatergic Neurons MAPT P301S/P301S}, {label=ioGlutamatergic Neurons MAPT N279K/WT, value=ioGlutamatergic Neurons MAPT N279K/WT}], media_contact=null, listing_button_label=View}, {hs_name=Rapid and consistent generation of functional microglia from reprogrammed hiPSCs to study neurodegeneration and neuroinflammation, hs_id=161961134491, hs_path=poster-rapid_and_consistent_generation_of_functional_ipsc_derived_microglia, button_label=View poster, button_link=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Product%20pages/ioMicroglia/bitbio-ioMicroglia_poster-V7-press_SfN%202022.pdf, type={label=Poster, value=Poster}, thumbnail={alt_text=, width=1504, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Emails/Header%20images/Header%20Images%20-%20ICC%20only/Microglia%20blog%20email%20header%20format.png, height=850}, year={label=2022, value=2022}, summary=<p>Raman, et al</p>
<p>bit.bio</p>
<p>2022</p>, date_published=1709251200000, sort_date=1669680000000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}, {label=ioMicroglia, value=ioMicroglia}], media_contact=null, listing_button_label=View}, {hs_name=Modelling neurodegeneration: Human isogenic system to study FTD & ALS, hs_id=161961134492, hs_path=ftd-als-mapt-tdp-43-disease-models-adpd-2023-poster-mar23, button_label=View poster, button_link=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Resources/bitbio_ioGlutamatergic%20Neurons%20MAPT%20TDP-43%20Disease%20Model%20poster_v2.pdf, type={label=Poster, value=Poster}, thumbnail={alt_text=, width=1966, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Product%20pages/MAPT%20N279K/N279K%20MAP2%20brightfield%20compressed%20rotated.png, height=1966}, year={label=2023, value=2023}, summary=<p>Oosterveen, et al</p>
<p>bit.bio & Charles River Laboratories</p>
<p>2023</p>, date_published=1709424000000, sort_date=1687478400000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}, {label=ioGlutamatergic Neurons HTT 50CAG/WT, value=ioGlutamatergic Neurons HTT 50CAG/WT}, {label=ioGlutamatergic Neurons TDP-43 M337V Het, value=ioGlutamatergic Neurons TDP-43 M337V Het}, {label=ioGlutamatergic Neurons TDP-43 M337V Hom, value=ioGlutamatergic Neurons TDP-43 M337V Hom}, {label=ioGlutamatergic Neurons MAPT P301S/WT, value=ioGlutamatergic Neurons MAPT P301S/WT}, {label=ioGlutamatergic Neurons MAPT P301S/P301S, value=ioGlutamatergic Neurons MAPT P301S/P301S}, {label=ioGlutamatergic Neurons MAPT N279K/WT, value=ioGlutamatergic Neurons MAPT N279K/WT}], media_contact=null, listing_button_label=View}, {hs_name=Generation and characterisation of a panel of human iPSC-derived neurons and microglia carrying early and late onset relevant mutations for Alzheimer’s disease, hs_id=161961134495, hs_path=slas2024-ad-poster, button_label=null, button_link=null, type={label=Poster, value=Poster}, thumbnail={alt_text=, width=1800, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Product%20pages/ioMicroglia/Microglia%20hero%202%20resize%20brighten%20v2%20compress.png, height=1800}, year={label=2024, value=2024}, summary=Smith, et al. <br>bit.bio<br>2024, date_published=1711065600000, sort_date=1708300800000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}, {label=ioGABAergic Neurons, value=ioGABAergic Neurons}, {label=ioMicroglia, value=ioMicroglia}], media_contact=Smith et al. <br>bit.bio<br>2024, listing_button_label=Download}, {hs_name=Lipid-Bilayer-Supported 3D Printing of Human Cerebral Cortex Cells Reveals Developmental Interactions , hs_id=161968263464, hs_path=lipid-bilayer-supported-3d-printing-of-human-cerebral-cortex-cells-reveals-developmental-interactions, button_label=Read more, button_link=https://onlinelibrary.wiley.com/doi/10.1002/adma.202002183, type={label=Publication, value=Publication}, thumbnail={alt_text=, width=666, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/BitBio2022/Resources/Resource-thumbs/resized/New%20Project%20(13).jpeg, height=428}, year={label=2020, value=2020}, summary=<p>Zhou L, et al </p>
<p><em>Advanced Science News</em></p>
<p>2020</p>
<p><a href="https://www.bit.bio/products/nerve-cells/glutamatergic-neurons-wild-type-io1001" rel="noopener" target="_blank">Using ioGlutamatergic Neurons</a></p>, date_published=1592092800000, sort_date=1598659200000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}], media_contact=<p>Zhou L, et al</p>
<p><em>Advanced Science News</em></p>
<p>2020</p>
<p>Using <a href="https://www.bit.bio/glutamatergic-neurons" rel="noopener">ioGlutamatergic Neurons</a></p>, listing_button_label=Read more}, {hs_name=Reprogramming the stem cell for a new generation of cures, hs_id=161968263465, hs_path=reprogramming-the-stem-cell-for-a-new-generation-of-cures, button_label=Read more, button_link=https://www.ddw-online.com/reprogramming-the-stem-cell-for-a-new-generation-of-cures-1459-202004/, type={label=Publication, value=Publication}, thumbnail={alt_text=, width=2092, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/bit.bio%20ioGlutamatergic%20Neurons%202022.jpg, height=1584}, year={label=2020, value=2020}, summary=<p>Davenport A, Frolov T & Kotter M</p>
<p><em>Drug Discovery World</em></p>
<p>2020</p>
<p> </p>
<p> </p>, date_published=1585872000000, sort_date=1597968000000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}, {label=ioSkeletal Myocytes, value=ioSkeletal Myocytes}, {label=ioGABAergic Neurons, value=ioGABAergic Neurons}, {label=ioMicroglia, value=ioMicroglia}, {label=ioSensory Neurons, value=ioSensory Neurons}, {label=ioMotor Neurons, value=ioMotor Neurons}, {label=ioAstrocytes, value=ioAstrocytes}], media_contact=<p><span>Davenport A, Frolov T & Kotter M.</span></p>
<p><em>Drug Discovery World</em></p>
<p>2020</p>
<p> </p>
<p> </p>, listing_button_label=Read more}, {hs_name=Inducible and Deterministic Forward Programming of Human Pluripotent Stem Cells into Neurons, Skeletal Myocytes, and Oligodendrocytes , hs_id=161968263466, hs_path=inducible-and-deterministic-forward-programming-of-human-pluripotent-stem-cells, button_label=Read more, button_link=https://www.cell.com/stem-cell-reports/fulltext/S2213-6711(17)30083-8, type={label=Publication, value=Publication}, thumbnail={alt_text=, width=759, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/publication-Inducible-and-deterministic-colour.jpg, height=461}, year={label=2017, value=2017}, summary=<p>Pawlowski M et al<br><em>Stem Cell Reports</em></p>
<p>2017</p>, date_published=1491868800000, sort_date=1499385600000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}], media_contact=<p><span>Pawlowski M, et al</span></p>
<p><em>Stem Cell Reports</em></p>
<p>2017</p>
<p> </p>, listing_button_label=Read more}, {hs_name=Compounds co-targeting kinases in axon regulatory pathways promote regeneration and behavioral recovery after spinal cord injury in mice, hs_id=161968263467, hs_path=compounds-co-targeting-kinases-in-axon-regulatory-pathways-promote-regeneration-and-behavioral-recovery-after-spinal-cord-injury-in-mice, button_label=Read more, button_link=https://pubmed.ncbi.nlm.nih.gov/35588791/, type={label=Publication, value=Publication}, thumbnail={alt_text=, width=1871, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Resources/Publications/bit.bio_single%20image_ioGlutamatergic%20Neurons%20Mah%20et%20al%202022.jpg, height=1417}, year={label=2022, value=2022}, summary=<p>Mah, et al</p>
<p><em>Experimental Neurology</em></p>
<p>2022</p>
<p>Using <a href="https://www.bit.bio/products/nerve-cells/glutamatergic-neurons-wild-type-io1001" rel="noopener" target="_blank">ioGlutamatergic Neurons</a></p>, date_published=1652659200000, sort_date=1667260800000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}], media_contact=<p>Mah, et al</p>
<p><em>Experimental Neurology</em></p>
<p>2022</p>
<p>Using <a href="https://www.bit.bio/glutamatergic-neurons" rel="noopener">ioGlutamatergic Neurons</a></p>, listing_button_label=Read more}, {hs_name=Glutamatergic Neurons and Brain Cyst Formation , hs_id=161968263468, hs_path=glutamatergic-neurons-and-brain-cyst-formation, button_label=Read more, button_link=https://www.frontiersin.org/articles/10.3389/fcimb.2021.788303/full, type={label=Publication, value=Publication}, thumbnail={alt_text=, width=2092, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/bit.bio%20ioGlutamatergic%20Neurons%202022.jpg, height=1584}, year={label=2022, value=2022}, summary=<p>Bando, et al</p>
<p><em>Frontiers in Cellular and Infection Microbiology</em></p>
<p>2022</p>
<p>Using<a href="https://www.bit.bio/products/nerve-cells/glutamatergic-neurons-wild-type-io1001" rel="noopener" target="_blank"> ioGlutamatergic Neurons</a></p>
<p> </p>
<p> </p>, date_published=1641859200000, sort_date=1667347200000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}], media_contact=<p>Bando, et al<br><br><em>Frontiers in Cellular and Infection Microbiology</em></p>
<p>2022</p>
<p>Using <a href="https://www.bit.bio/glutamatergic-neurons" rel="noopener">ioGlutamatergic Neurons</a></p>, listing_button_label=Read more}, {hs_name=Interferon-γ exposure of human iPSC-derived neurons alters major histocompatibility complex I and synapsin protein expression , hs_id=161968263469, hs_path=interferon-γ-exposure-of-human-ipsc-derived-neurons-alters-major-histocompatibility-complex-i-and-synapsin-protein-expression, button_label=Read more, button_link=https://www.frontiersin.org/articles/10.3389/fpsyt.2022.836217/full, type={label=Publication, value=Publication}, thumbnail={alt_text=, width=3742, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Resources/Publications/bit.bio%20ioGlutamatergic%20Neurons%20pavlinek%20et%20al%202022.jpg, height=2836}, year={label=2022, value=2022}, summary=<p>Pavinlek, et al</p>
<p><em>Frontiers in Psychiatry</em></p>
<p>2022</p>
<p>Using <a href="https://www.bit.bio/products/nerve-cells/glutamatergic-neurons-wild-type-io1001" rel="noopener" target="_blank">ioGlutamatergic Neurons</a></p>
<p> </p>
<p> </p>, date_published=1663113600000, sort_date=1667433600000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}], media_contact=<p>Pavinlek, et al<br><br><em>Frontiers in Psychiatry</em></p>
<p>2022</p>
<p>Using <a href="https://www.bit.bio/glutamatergic-neurons" rel="noopener">ioGlutamatergic Neurons</a></p>, listing_button_label=Read more}, {hs_name=Rewiring of the promoter-enhancer interactome and regulatory landscape in glioblastoma orchestrates gene expression underlying neurogliomal synaptic communication, hs_id=178039124124, hs_path=rewiring-of-the-promoter-nature-article, button_label=Read more, button_link=https://www.nature.com/articles/s41467-023-41919-x, type={label=Publication, value=Publication}, thumbnail={alt_text=bitbio-ioGlutamatergic-Neurons, width=1700, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Product%20pages/ioGlutamatergic%20Neurons/bitbio-ioGlutamatergic-Neurons.jpg, height=1300}, year={label=2023, value=2023}, summary=<p>Chakraborty et al<br><em>Nature Communications</em><br>2023</p>
<p>Featuring <a href="https://www.bit.bio/products/nerve-cells/glutamatergic-neurons-wild-type-io1001" rel="noopener" target="_blank">ioGlutamatergic Neurons</a></p>, date_published=1697155200000, sort_date=1697155200000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}], media_contact=<p>Chakraborty et al<br><em>Nature Communications</em><br>2023</p>
<p>Featuring <a href="https://www.bit.bio/products/nerve-cells/glutamatergic-neurons-wild-type-io1001" rel="noopener" target="_blank">ioGlutamatergic Neurons</a></p>, listing_button_label=Read more}, {hs_name=HNRNPH1 regulates the neuroprotective cold‐shock protein RBM3 expression through poison exon exclusion, hs_id=178039124146, hs_path=hnrnph1-regulates-the-neuroprotective-cold-shock-protein-rbm3-expression-through-poison-exon-exclusion-article, button_label=Read more, button_link=https://www.embopress.org/doi/full/10.15252/embj.2022113168, type={label=Publication, value=Publication}, thumbnail={alt_text=bitbio-ioGlutamatergic-Neurons, width=1700, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Product%20pages/ioGlutamatergic%20Neurons/bitbio-ioGlutamatergic-Neurons.jpg, height=1300}, year={label=2023, value=2023}, summary=<p>Qiaojin Lin et al</p>
<p><em>The EMBO Journal</em></p>
<p>2023</p>
<p>Featuring opti-ox powered hiPSC-derived <a href="https://www.bit.bio/products/nerve-cells/glutamatergic-neurons-wild-type-io1001" rel="noopener" target="_blank">glutamatergic neurons</a> with constitutive expression of Cas9</p>, date_published=1685404800000, sort_date=1685404800000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}], media_contact=<p>Qiaojin Lin et al</p>
<p><em>The EMBO Journal</em></p>
<p>2023</p>
<p>Featuring opti-ox powered hiPSC-derived <a href="https://www.bit.bio/products/nerve-cells/glutamatergic-neurons-wild-type-io1001" rel="noopener" target="_blank">glutamatergic neurons</a> with constitutive expression of Cas9</p>, listing_button_label=Read more}, {hs_name=Schizophrenia risk gene ZNF804A controls ribosome localization and synaptogenesis in developing human neurons, hs_id=178046423390, hs_path=schizophrenia-risk-gene-znf804a-controls-ribosome-localization-and-synaptogenesis-in-developing-human-neurons-article, button_label=Read more, button_link=https://www.biorxiv.org/content/10.1101/2024.02.02.578424v1, type={label=Publication, value=Publication}, thumbnail={alt_text=bitbio-ioGlutamatergic-Neurons, width=1700, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Product%20pages/ioGlutamatergic%20Neurons/bitbio-ioGlutamatergic-Neurons.jpg, height=1300}, year={label=2024, value=2024}, summary=<p><span>Deepak P.</span><span> </span><span>Srivastava, et al</span></p>
<p><em>bioRxiv</em></p>
<p>2024</p>
<p>Featuring <a href="https://www.bit.bio/platform" rel="noopener" target="_blank">opti-ox </a>enabled glutamatergic neurons iPS cell line</p>, date_published=1706832000000, sort_date=1706832000000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}], media_contact=<p><span>Deepak P.</span><span> </span><span>Srivastava, et al</span></p>
<p><em>bioRxiv</em></p>
<p>2024</p>
<p>Featuring <a href="https://www.bit.bio/platform" rel="noopener" target="_blank">opti-ox</a><sup> </sup>enabled glutamatergic neurons iPS cell line</p>, listing_button_label=Read more}, {hs_name=Circadian clocks in human cerebral organoids, hs_id=178051600304, hs_path=circadian-clocks-in-human-cerebral-organoids-article, button_label=Read more, button_link=https://www.biorxiv.org/content/10.1101/2024.02.20.580978v1.full, type={label=Publication, value=Publication}, thumbnail={alt_text=Hero image_CRISPR-Ready ioMicroglia, width=1422, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Product%20pages/ioMicroglia/Hero%20image_CRISPR-Ready%20ioMicroglia.png, height=1920}, year={label=2024, value=2024}, summary=<p>Rzechorzek, et al</p>
<p><em>bioRxiv</em></p>
<p>2024</p>
<p>Featuring <a href="https://www.bit.bio/platform" rel="noopener" target="_blank">opti-ox</a><sup> </sup>enabled microglia male iPS cell line and opti-ox enabled glutamatergic neurons iPS cell line</p>, date_published=1708473600000, sort_date=1708473600000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}, {label=ioMicroglia, value=ioMicroglia}], media_contact=<p>Rzechorzek, et al</p>
<p><em>bioRxiv</em></p>
<p>2024</p>
<p>Featuring <a href="https://www.bit.bio/platform" rel="noopener" target="_blank">opti-ox</a><sup> </sup>enabled microglia male iPS cell line and opti-ox enabled glutamatergic neurons iPS cell line</p>, listing_button_label=Read more}, {hs_name=CRISPR and the Art of Perturbation Screening: Unbiased functional genomic screening meets the best human cellular models, hs_id=161968263475, hs_path=crispr-and-the-art-of-perturbation-screening-unbiased-functional-genomic-screening-meets-the-best-human-cellular-models, button_label=Explore ioCRISPR-Ready Cells, button_link=https://www.bit.bio/iocrispr-ready, type={label=Talk, value=Talk}, thumbnail={alt_text=, width=1318, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/BitBio2022/Resources%20listing/hubdb-thumbs/resources/CRISPR%20and%20the%20Art%20of%20Perturbation%20Screening-min.png, height=1000}, year={label=2021, value=2021}, summary=<p>Kam Dhaliwal <span>| </span>SVP Strategic Alliances | bit.bio</p>
<p><br>Talk at ELRIG CRISPR in Drug Discovery</p>, date_published=1706140800000, sort_date=1636070400000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}, {label=ioSkeletal Myocytes, value=ioSkeletal Myocytes}, {label=ioGlutamatergic Neurons HTT 50CAG/WT, value=ioGlutamatergic Neurons HTT 50CAG/WT}, {label=ioSensory Neurons, value=ioSensory Neurons}], media_contact=null, listing_button_label=Watch now}, {hs_name=Consistent and scalable human iPSC-derived cells for in vitro disease modelling and drug discovery, hs_id=161968263476, hs_path=consistent-and-scalable-human-ipsc-derived-cells-for-in-vitro-disease-modelling-and-drug-discovery, button_label=Explore ioCells, button_link=https://www.bit.bio/discover-iocells, type={label=Talk, value=Talk}, thumbnail={alt_text=, width=900, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/DDD_banner_square.jpeg, height=652}, year={label=2020, value=2020}, summary=<p>Kam Dhaliwal <span>| </span> SVP Strategic Alliances | bit.bio<br>Dr Thomas Moreau <span>|</span> Head of Research | bit.bio</p>
<p><br>Talk at ELRIG Drug Discovery Digital</p>, date_published=1706400000000, sort_date=1600905600000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}, {label=ioSkeletal Myocytes, value=ioSkeletal Myocytes}, {label=ioGlutamatergic Neurons HTT 50CAG/WT, value=ioGlutamatergic Neurons HTT 50CAG/WT}], media_contact=null, listing_button_label=Watch now}, {hs_name=Precision Cellular Reprogramming for Scalable and Consistent Human Neurodegenerative Disease Models, hs_id=161968263479, hs_path=precision-cellular-reprogramming-for-scalable-and-consistent-human-neurodegenerative-disease-models, button_label=Explore ioDisease Model Cells, button_link=https://www.bit.bio/iodisease-models, type={label=Talk, value=Talk}, thumbnail={alt_text=, width=1860, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Resources/Tech%20Nets%20online%20symposium%20header%20(1).png, height=1260}, year={label=2023, value=2023}, summary=<p>Madeleine Garrett | Field Application Specialist | bit.bio</p>, date_published=1709078400000, sort_date=1681344000000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}, {label=ioGlutamatergic Neurons HTT 50CAG/WT, value=ioGlutamatergic Neurons HTT 50CAG/WT}, {label=ioMicroglia, value=ioMicroglia}, {label=ioGlutamatergic Neurons TDP-43 M337V Het, value=ioGlutamatergic Neurons TDP-43 M337V Het}, {label=ioGlutamatergic Neurons TDP-43 M337V Hom, value=ioGlutamatergic Neurons TDP-43 M337V Hom}, {label=ioGlutamatergic Neurons MAPT P301S/WT, value=ioGlutamatergic Neurons MAPT P301S/WT}, {label=ioGlutamatergic Neurons MAPT P301S/P301S, value=ioGlutamatergic Neurons MAPT P301S/P301S}, {label=ioGlutamatergic Neurons MAPT N279K/WT, value=ioGlutamatergic Neurons MAPT N279K/WT}, {label=ioOligodendrocyte-like cells, value=ioOligodendrocyte-like cells}, {label=ioMotor Neurons, value=ioMotor Neurons}], media_contact=null, listing_button_label=Watch now}, {hs_name=Industrialising Cellular Reprogramming: Leveraging opti-ox Technology to Manufacture Human Cells with Unprecedented Consistency, hs_id=161968263480, hs_path=industrialising-cellular-reprogramming-leveraging-opti-ox-technology-to-manufacture-human-cells-with-unprecedented-consistency, button_label=null, button_link=null, type={label=Talk, value=Talk}, thumbnail={alt_text=, width=1024, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Resources/Resources/video/Squarespace+Thumbnail+Template+-+AM23-01-01-01.png, height=768}, year={label=2023, value=2023}, summary=<p>Innovation showcase talk at ISSCR</p>
<p>Marius Wernig MD, PhD | Stanford </p>
<p>Mark Kotter, MD, PhD | bit.bio</p>, date_published=1709683200000, sort_date=1688083200000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}, {label=ioGABAergic Neurons, value=ioGABAergic Neurons}, {label=ioSensory Neurons, value=ioSensory Neurons}, {label=CRISPR-Ready ioCells, value=CRISPR-Ready ioCells}], media_contact=<p>V1<br><br>2023<br><br>ISSCR 2023</p>, listing_button_label=Watch now}, {hs_name=ioGlutamatergic Neurons Wild Type and related disease models | User Manual, hs_id=161968263487, hs_path=glutamatergic-neurons, button_label=null, button_link=null, type={label=User manual, value=User manual}, thumbnail={alt_text=bit-bio ioGlutamatergic Neurons Day 14 Beta III Tubulin staining copy, width=1200, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/ioGlutamatergic%20Neurons%20in%20Drug%20Discovery/bit-bio%20ioGlutamatergic%20Neurons%20Day%2014%20Beta%20III%20Tubulin%20staining%20copy.jpeg, height=1200}, year={label=2024, value=2024}, summary=<p>V11</p>
<p>bit.bio</p>
<p>2024</p>, date_published=1707955200000, sort_date=1713225600000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}, {label=ioGlutamatergic Neurons HTT 50CAG/WT, value=ioGlutamatergic Neurons HTT 50CAG/WT}, {label=ioGlutamatergic Neurons TDP-43 M337V Het, value=ioGlutamatergic Neurons TDP-43 M337V Het}, {label=ioGlutamatergic Neurons TDP-43 M337V Hom, value=ioGlutamatergic Neurons TDP-43 M337V Hom}, {label=ioGlutamatergic Neurons MAPT P301S/WT, value=ioGlutamatergic Neurons MAPT P301S/WT}, {label=ioGlutamatergic Neurons MAPT P301S/P301S, value=ioGlutamatergic Neurons MAPT P301S/P301S}, {label=ioGlutamatergic Neurons MAPT N279K/WT, value=ioGlutamatergic Neurons MAPT N279K/WT}, {label=ioAstrocytes, value=ioAstrocytes}, {label=Product information, value=Product information}], media_contact=<p><span>V11</span></p>
<p><span>bit.bio</span></p>
<p><span>2024</span></p>, listing_button_label=Download}, {hs_name=Partnering with Charles River to advance CNS drug discovery with ioGlutamatergic Neurons, hs_id=161968263497, hs_path=in-conversation-with-charles-river-video-part-2, button_label=null, button_link=null, type={label=Video, value=Video}, thumbnail={alt_text=, width=687, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/CRL%20video%20posts/crl%202%20webpage%20image-2.png, height=476}, year={label=2021, value=2021}, summary=<p>Dr Marijn Vlaming | Head of Biology, et al.</p>
<p>Charles River & bit.bio</p>, date_published=1705017600000, sort_date=1637107200000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}, {label=ioGlutamatergic Neurons TDP-43 M337V Het, value=ioGlutamatergic Neurons TDP-43 M337V Het}, {label=ioGlutamatergic Neurons TDP-43 M337V Hom, value=ioGlutamatergic Neurons TDP-43 M337V Hom}], media_contact=null, listing_button_label=Watch }, {hs_name=In Conversation with Charles River, hs_id=161968263498, hs_path=in-conversation-with-charles-river-video, button_label=Discover our ioCells portfolio, button_link=/discover-iocells, type={label=Video, value=Video}, thumbnail={alt_text=, width=834, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/CRL%20video%20posts/CRL%20video%20%231%20card%20for%20webpage%20(thinner%20gradient%20line)-1.png, height=590}, year={label=2021, value=2021}, summary=<p>Dr Marijn Vlaming <span>|</span> Head of Biology<br>Charles River</p>, date_published=1705363200000, sort_date=1636675200000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}], media_contact=null, listing_button_label=Watch}, {hs_name=Culturing Glutamatergic Neurons | How-to Video, hs_id=161966111374, hs_path=how-to-culture-ioglutamatergic-neurons, button_label=Download the user manual, button_link=/resources/ioglutamatergic-neurons-user-manual, type={label=Video tutorial, value=Video tutorial}, thumbnail={alt_text=, width=1318, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/BitBio2022/Resources%20listing/hubdb-thumbs/resources/How%20to%20prepare%20tissue%20culture%20vessels%20with%20PDL-Geltrex-min.png, height=1000}, year={label=2021, value=2021}, summary=<p>Dr Kaiser Karim <span>|</span> Scientist<br>bit.bio</p>, date_published=1705104000000, sort_date=1637020800000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}, {label=ioGlutamatergic Neurons TDP-43 M337V Het, value=ioGlutamatergic Neurons TDP-43 M337V Het}, {label=ioGlutamatergic Neurons TDP-43 M337V Hom, value=ioGlutamatergic Neurons TDP-43 M337V Hom}], media_contact=null, listing_button_label=Watch now}, {hs_name=Preparing Culture Vessels for Glutamatergic Neurons | How-to Video, hs_id=161966111375, hs_path=how-to-prepare-tissue-culture-vessels-with-pdl-geltrex, button_label=Watch the next video, button_link=/resources/how-to-culture-ioglutamatergic-neurons, type={label=Video tutorial, value=Video tutorial}, thumbnail={alt_text=, width=1318, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/BitBio2022/Resources%20listing/hubdb-thumbs/resources/How%20to%20culture%20ioGlutamatergic%20Neurons-min.png, height=1000}, year={label=2021, value=2021}, summary=<p>Dr Kaiser Karim <span>|</span> Scientist<br>bit.bio</p>, date_published=1705190400000, sort_date=1636934400000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}, {label=ioGlutamatergic Neurons TDP-43 M337V Het, value=ioGlutamatergic Neurons TDP-43 M337V Het}, {label=ioGlutamatergic Neurons TDP-43 M337V Hom, value=ioGlutamatergic Neurons TDP-43 M337V Hom}], media_contact=null, listing_button_label=Watch now}, {hs_name=Modelling neurodevelopment | Investigating the impact of maternal immune activation on neurodevelopment using human iPSC-derived cells, hs_id=161968263519, hs_path=modelling-neurodevelopment-webinar-2022, button_label=Explore ioGlutamatergic Neurons, button_link=https://www.bit.bio/products/nerve-cells/glutamatergic-neurons-wild-type-io1001, type={label=Webinar, value=Webinar}, thumbnail={alt_text=, width=1200, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/BitBio2022/product-page/Colour%20webinar%20with%2060x%20Map2-com.jpg, height=732}, year={label=2022, value=2022}, summary=<p><span>Dr Deepak Srivastava | King’s College London<br><br></span><span></span></p>, date_published=1707436800000, sort_date=1649376000000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}, {label=ioGABAergic Neurons, value=ioGABAergic Neurons}], media_contact=null, listing_button_label=Watch now}, {hs_name=Rethinking Developmental Biology With Cellular Reprogramming, hs_id=161968263524, hs_path=rethinking-developmental-biology-with-cellular-reprogramming, button_label=Explore ioCells, button_link=https://www.bit.bio/discover-iocells, type={label=Webinar, value=Webinar}, thumbnail={alt_text=, width=1860, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Upcoming%20Webinars/Tech%20Nets%202023/bit.bio_ioGlutamatergic%20Neurons_20xMAP2(red)Hoescht(blue)_day12v2.png, height=1260}, year={label=2023, value=2023}, summary=<p>Mark Kotter | CEO and founder | bit.bio</p>
<p>Marius Wernig | Professor Departments of Pathology and Chemical and Systems Biology | Stanford University</p>, date_published=1709164800000, sort_date=1681776000000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}, {label=ioGABAergic Neurons, value=ioGABAergic Neurons}, {label=ioMicroglia, value=ioMicroglia}, {label=Cell therapy, value=Cell therapy}, {label=ioSensory Neurons, value=ioSensory Neurons}, {label=ioOligodendrocyte-like cells, value=ioOligodendrocyte-like cells}], media_contact=null, listing_button_label=Watch now}, {hs_name=Addressing the Reproducibility Crisis | Driving Genome-Wide Consistency in Cellular Reprogramming, hs_id=161968263525, hs_path=addressing-the-reproducibility-crisis-driving-genome-wide-consistency-in-cellular-reprogramming, button_label=Explore ioCells, button_link=https://www.bit.bio/discover-iocells, type={label=Webinar, value=Webinar}, thumbnail={alt_text=, width=1860, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Upcoming%20Webinars/Tech%20Nets%2019th%20July%202023/bit.bio_ioGlutamatergic%20Neurons_60xMAP2(red)Hoescht(blue)TUBB3(blue)_day4.jpg, height=1260}, year={label=2023, value=2023}, summary=<p>Dr Ania Wilczynska | Head of Computational Genomics | Non-Clinical | bit.bio</p>, date_published=1709769600000, sort_date=1689724800000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}, {label=ioGABAergic Neurons, value=ioGABAergic Neurons}, {label=ioSensory Neurons, value=ioSensory Neurons}, {label=CRISPR-Ready ioGlutamatergic Neurons, value=CRISPR-Ready ioGlutamatergic Neurons}], media_contact=null, listing_button_label=Watch now}, {hs_name=Running Large-Scale CRISPR Screens in Human Neurons, hs_id=161968263528, hs_path=running-large-scale-crispr-screens-in-human-neurons, button_label=null, button_link=null, type={label=Webinar, value=Webinar}, thumbnail={alt_text=, width=1200, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Emails/Header%20images/Header%20Images%20-%20ICC%20only/Running%20Large-Scale%20CRISPR%20Screens%20in%20Human%20Neurons_email%20header.png, height=678}, year={label=2023, value=2023}, summary=<p>Emmanouil Metzakopian | Vice President, Research and Development | bit.bio</p>
<p>Javier Conde-Vancells | Director Product Management | bit.bio</p>, date_published=1710460800000, sort_date=1700524800000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}, {label=CRISPR-Ready ioCells, value=CRISPR-Ready ioCells}, {label=CRISPR-Ready ioGlutamatergic Neurons, value=CRISPR-Ready ioGlutamatergic Neurons}, {label=CRISPR-Ready ioMicroglia, value=CRISPR-Ready ioMicroglia}], media_contact=null, listing_button_label=Watch now}, {hs_name=Human iPSC-Based Models of Glial Cells for Studying Neurodegenerative Disease, hs_id=183096620633, hs_path=human-ipsc-based-models-of-glial-cells-for-studying-neurodegenerative-disease, button_label=null, button_link=null, type={label=Webinar, value=Webinar}, thumbnail={alt_text=bitbio-oligodendrocyte-like-cells-O4-MBP-immunocytochemistry, width=1000, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Product%20pages/ioOligodendrocyte-like%20cells/bitbio-oligodendrocyte-like-cells-O4-MBP-immunocytochemistry.jpg, height=1350}, year={label=2024, value=2024}, summary=Valentina Fossati, PhD | Senior Research Investigator | The New York Stem Cell Foundation<br><br>Inês Ferreira | Senior Product Manager | bit.bio, date_published=1732233600000, sort_date=1732233600000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}, {label=ioOligodendrocyte-like cells, value=ioOligodendrocyte-like cells}], media_contact=null, listing_button_label=Watch now}])
Hoescht(blue)TUBB3(blue)_day4.jpg?width=604&name=bit.bio_ioGlutamatergic%20Neurons_60xMAP2(red)Hoescht(blue)TUBB3(blue)_day4.jpg)
Hoescht(blue)_day12v2.png?width=604&name=bit.bio_ioGlutamatergic%20Neurons_20xMAP2(red)Hoescht(blue)_day12v2.png)
Human iPSC-Based Models of Glial Cells for Studying Neurodegenerative Disease
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Producing 3D Neuronal Microtissues for Preclinical Drug Screening using ioGlutamatergic Neurons
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Sartorius application note - Advanced in vitro Modeling of Human iPSC-derived Neuronal Mono- and Co-cultures with Microglia
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ioGlutamatergic Neurons
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ioGlutamatergic Neurons Wild Type and related disease models | User Manual
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Circadian clocks in human cerebral organoids
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Generation and characterisation of a panel of human iPSC-derived neurons and microglia carrying early and late onset relevant mutations for Alzheimer’s disease
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Schizophrenia risk gene ZNF804A controls ribosome localization and synaptogenesis in developing human neurons
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Generating publishable neuroscience research in 12 weeks with ioGlutamatergic Neurons
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Running Large-Scale CRISPR Screens in Human Neurons
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Rewiring of the promoter-enhancer interactome and regulatory landscape in glioblastoma orchestrates gene expression underlying neurogliomal synaptic communication
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Addressing the Reproducibility Crisis | Driving Genome-Wide Consistency in Cellular Reprogramming
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Industrialising Cellular Reprogramming: Leveraging opti-ox Technology to Manufacture Human Cells with Unprecedented Consistency
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Modelling neurodegeneration: Human isogenic system to study FTD & ALS
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HNRNPH1 regulates the neuroprotective cold‐shock protein RBM3 expression through poison exon exclusion
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Rethinking Developmental Biology With Cellular Reprogramming
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Cell culture hacks | human iPSC-derived glutamatergic neurons
Read this blog on glutamatergic neuron cell culture for our top tips on careful handling, cell plating and media changes to achieve success from the outset.
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ioDisease Model Cells
ioGlutamatergic Neurons PSEN1 M146L/WT
cat no | io1072
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ioWild Type Cells
ioGlutamatergic Neurons
cat no | io1001
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ioDisease Model Cells
ioGlutamatergic Neurons APP KM670/671NL/WT
cat no | io1061
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ioDisease Model Cells
ioGlutamatergic Neurons APP V717I/WT
cat no | io1067
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ioDisease Model Cells
ioGlutamatergic Neurons APP KM670/671NL / KM670/671NL
cat no | io1059
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ioDisease Model Cells
ioGlutamatergic Neurons APP V717I/V717I
cat no | io1063
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CRISPR-Ready ioCells
CRISPR-Ready ioGlutamatergic Neurons
cat no | io1090
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Wild Type and Isogenic Disease Model cells: A true comparison
Further your disease research by pairing our wild type cells with isogenic disease models.
