Modelling Alzheimer's disease with human iPSC-derived cells

Consistent, defined and scalable human iPSC-derived disease models for Alzheimer's disease research and drug discovery

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Alzheimer's disease, the most common type of dementia, is a neurodegenerative disorder that progressively undermines patients' cognitive abilities, impairing their capacity to create and retrieve memories. Studying Alzheimer’s disease remains a significant challenge, in part because of difficulties accurately emulating the disease's pathophysiology in vitro.

There is a pressing need for an in vitro model of Alzheimer's disease that can be used to accurately and reliably study the effect of disease-associated mutations, disease progression and to identify potential therapeutic targets. ioDisease Model Cells provide scientists with defined, consistent and scalable human iPSC-derived cells engineered with common monogenic Alzheimer’s disease-related mutations, helping improve the translatability of in vitro research. 

Discover ioDisease Model Cells for modelling Alzheimer’s disease in vitro below.

Alzheimer's disease models in ioMicroglia

ioMicroglia TREM2 R47H/WT ioDisease Model Cells
ioMicroglia TREM2 R47H/WT cat no | io1038
ioMicroglia TREM2 R47H/R47H ioDisease Model Cells
ioMicroglia TREM2 R47H/R47H cat no | io1035
ioMicroglia APOE 4/3 C112R/WT ioDisease Model Cells
ioMicroglia APOE 4/3 C112R/WT cat no | io1033
ioMicroglia APOE 4/4 C112R/C112R ioDisease Model Cells
ioMicroglia APOE 4/4 C112R/C112R cat no | io1032

Alzheimer's disease models in ioGlutamatergic Neurons

ioGlutamatergic Neurons APP V717I/V717I ioDisease Model Cells
ioGlutamatergic Neurons APP V717I/V717I cat no | io1063
ioGlutamatergic Neurons APP V717I/WT ioDisease Model Cells
ioGlutamatergic Neurons APP V717I/WT cat no | io1067
ioGlutamatergic Neurons APP KM670/671NL/WT ioDisease Model Cells
ioGlutamatergic Neurons APP KM670/671NL/WT cat no | io1061
ioGlutamatergic Neurons APP KM670/671NL / KM670/671NL ioDisease Model Cells
ioGlutamatergic Neurons APP KM670/671NL / KM670/671NL cat no | io1059
ioGlutamatergic Neurons PSEN1 M146L/M146L ioDisease Model Cells
ioGlutamatergic Neurons PSEN1 M146L/M146L cat no | io1069
ioGlutamatergic Neurons PSEN1 M146L/WT ioDisease Model Cells
ioGlutamatergic Neurons PSEN1 M146L/WT cat no | io1072

Alzheimer's disease models in ioGABAergic Neurons

ioGABAergic Neurons APP V717I/WT ioDisease Model Cells
ioGABAergic Neurons APP V717I/WT cat no | io1084 | io1085
ioGABAergic Neurons APP V717I/V717I ioDisease Model Cells
ioGABAergic Neurons APP V717I/V717I cat no | io1081 | io1082

Pair ioDisease Model Cells with a genetically matched control

ioMicroglia | Male ioWild Type Cells
ioMicroglia | Male cat no | io1021
ioGlutamatergic Neurons ioWild Type Cells
ioGlutamatergic Neurons cat no | io1001
ioGABAergic Neurons ioWild Type Cells
ioGABAergic Neurons cat no | io1003

Start effortlessly with our library of applications and protocols

Tri-culture of ioGlutamatergic Neurons, ioGABAergic Neurons and astrocytes protocol (2)

Study functional neural networks

Modelling of cellular interactions by culturing excitatory and inhibitory neurons with astrocytes.

Tri-culture protocol
Website Resources Cards_Quantifying C5a-mediated chemotaxis in precision reprogrammed hiPSC-derived ioMicroglia

Model disease progression

Learn how to study the role of C5a and other proteins in driving neuroinflammation.

Access the application note
ioMicroglia cytokine release

Analyse cytokine profiles

Investigate potential therapeutic compounds that can modulate microglial activation by measuring changes in cytokine secretion.

Stimulation for cytokine release protocol

Validated through real-world applications and results

Disease related phenotye - Data

Study disease-related phenotypes

Quantification of 𝛽-amyloid peptide secretion in an Alzheimer’s disease model toolkit with a genetically matched control.

V-PLEX A𝛽 peptide data
Case study

Building consistent in vitro assays for CNS drug development

Learn how ioMicroglia offered Concept Life Sciences functional cells with low inter-lot variability, ensuring consistent assay performance, facilitating large scale screening studies.

Read the case study
App note - inventia

Scalable 3D models for screening

Find out how Inventia Life Science generated functional 3D neuronal models in 96- and 384-well formats that closely resembled the human brain.

Access the application note
bb-card-image-520-x-360-1-CaseStudy-SpeedingUpResearch (1)

Quickly identify disease risk factors

Discover how Professor Srivastava, King's College London, generated publishable data in just 12 weeks.

Read the case study

Easily conduct your own Alzheimer's disease-related gene knockouts, activation and interference experiments with CRISPR-Ready ioCells 

CRISPR-Ready ioCells offer a fast and simple toolkit for gene editing in human iPSC-derived neurons and glia. Engineered to constitutively express Cas9 nuclease or dCas9 variants, these cells enable scientists to easily knockout, activate or interfere with their gene of interest in physiologically relevant cells in a matter of days. 

Discover CRISPR-Ready ioCells
ioGlutamatergic-Neurons-CRISPR-Ready-Hero-Image square

Don’t see what you’re looking for? Partner with us to generate custom ioDisease Model Cells to study Alzheimer's disease

Access our platform to generate custom ioCells to precisely answer your drug discovery and disease research questions.

Learn more about our custom ioDisease Model Cells offering
bit.bio lab scientist with sample

Related pages

Discover ioCells Learn about our range of human iPSC-derived cells for research and drug discovery
Resources Explore our latest scientific insights, webinars, blogs and videos
Our platform Discover the cell identity coding platform behind our cells