bit.bio launches ioAstrocytes

For the first time, scientists can now leverage the reproducibility of ioCells to study how the four major CNS cell types interact and contribute to neurological diseases. This enables more precise research and opens new doors for developing effective treatments.

• Human astrocytes are key to developing effective in-vitro models of the central nervous system (CNS), enabling the study and testing of new treatments for neurological and neurodegenerative diseases.

• ioAstrocytes, the newest addition to bit.bio’s ioCells CNS toolkit, are highly characterized and functional, offering consistent results and addressing the variability issues associated with primary astrocytes.

• Designed for ease of use with open-source media and protocols, ioAstrocytes can be co-cultured with other brain cells, including bit.bio’s ioCells range, allowing researchers to model brain complexity and gain valuable insights into disease mechanisms and treatments.
  

CAMBRIDGE, UK, 14:00, 19 June 2024 - bit.bio, the company coding human cells for novel cures and a pioneer in the field of synthetic biology, today announces the launch of ioAstrocytes. This new addition to bit.bio’s ioCells portfolio creates an unparalleled toolkit for disease research that addresses the challenges of data reproducibility and enables accelerated therapeutic development.

ioCells, iPSC-derived cells for research and drug discovery, are manufactured using bit.bio's deterministic programming technology, opti-ox, and are considered best in class for their functionality, consistency, and scalability. With 18 launches to date in 2024, bit.bio’s ioCells portfolio comprises 37 products, including ioWild Type Cells, ioDisease Model Cells and ioCRISPR-Ready Cells.

Astrocytes are a type of glial cell in the brain involved in a wide range of processes, including neural signalling, homeostasis maintenance, and immune response regulation. The significance of astrocytes for effectively modelling the human brain is frequently underestimated. Growing evidence highlights the important role of astrocytes in CNS conditions, such as multiple sclerosis, Alzheimer’s disease, Parkinson’s disease, epilepsy, pain disorders, and neuropsychiatric conditions. With the introduction of ioAstrocytes, scientists now have access to defined, consistent, and functional human astrocytes optimised for co-culture with other CNS cell types.

"We are excited to expand the universe of ioCells with ioAstrocytes and offer researchers worldwide access to the major cell types of the human brain. Much like building blocks, scientists can combine different CNS cell types with or without disease-specific mutations to explore their interactions. We look forward to seeing how the neuroscience community will leverage this powerful toolkit to further our understanding of the CNS and develop much needed therapies for neurological conditions."

Mark KotterCo-founder and CEO, bit.bio

ioAstrocytes are highly defined, consistent, and functional human astrocytes, optimised for co-culture with other CNS cell types. They display stellate morphology, express key markers, and perform essential astrocyte functions such as phagocytosis, secretion of cytokines, and modulation of neuronal activity when co-cultured with CNS cells.

"ioAstrocytes represent a significant addition to bit.bio's growing ioCells portfolio, enabling researchers to enhance in-vitro CNS models and accelerate discoveries. By providing highly consistent cells with essential functional properties of human astrocytes, we’re unlocking novel ways for advancing neuroinflammation research, conducting in-depth neural network studies, and performing screening and toxicity assessments for potential therapeutics."

Farah Patell-Sochabit.bio VP Research Products

For more information or to purchase ioAstrocytes please visit.