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CRISPR-Ready ioCells
How CRISPR-Ready ioCells will transform your functional genomics workflows
Go beyond immortalised cells for gene knockouts and CRISPR screens
Routinely generate high-efficiency knockouts in defined, consistent and functional human cells that can scale to CRISPR screening workflows.
Everything is already optimised for you
Our optimised cell culture and guide delivery protocols mean you only need to refine your guide RNA designs to generate high efficiency gene knockouts.
Generate high-efficiency gene knockouts in a matter of days
The cells are delivered cryopreserved, ready for guide delivery by transfection or transduction within days post-thaw.
See how CRISPR-Ready ioCells can be used to rapidly generate gene knockouts and CRISPR screens
First presented at the 6th Annual Neuroimmunology Drug Development Summit 2024, this poster demonstrates how high-efficiency gene knockouts can be achieved in CRISPR-Ready ioMicroglia using both lentiviral and lipid-based gRNA delivery methods. It also showcases a CRISPR knockout screen in CRISPR-Ready ioMicroglia that identified 17 genes responsible for modulating LPS-induced innate immune responses.
See how opti-ox powered cells empower researchers to push the boundaries of CRISPR screens
Watch this webinar to hear from Emmanouil Metzakopian, PhD, Senior Vice President of Science at bit.bio, and former UK Dementia Research Group Leader. He discusses his lab's recently published research using opti-ox-powered iPSC-derived cells constitutively expressing Cas9 to generate large-scale CRISPR screens to identify new therapeutic targets for the treatment of neurodegenerative diseases.
Go from cell seeding to gene knockout in days
Our expert team is on hand to help you ensure success with every experiment
Access support from our expert scientific team at any time. With decades of hands-on CRISPR experience, the team is available to provide advice on your next CRISPR experiment.
Custom CRISPR screens and CRISPR-Ready ioCell development
If we don't currently have the cells your target identification and validation workflows need, our team of experts can develop new CRISPR-Ready ioCells in any ioWild Type Cell background. Additionally, if you are looking to outsource the development of high throughput CRISPR screens in CRISPR-Ready ioCells, we can design, build and run these for you.
Browse ioCells portfolio
ioWild Type Cells
ioWild Type Cells are defined, easy-to-use, functional iPSC-derived human cells from a healthy donor background that are ready for fundamental research and drug discovery experimentation within days.
ioDisease Model Cells
ioDisease Model Cells are ioWild Type Cells engineered to contain disease-relevant mutations. ioDisease Model Cells and ioWild Type Cells form an isogenic pair allowing scientists to make true comparisons.
Custom Cell Development
We provide our partners with the ability to develop and access any human cell type at scale, removing the experimental burden of cell models that are not translatable, scalable or an accurate representation of disease.
Custom ioDisease Model Cells
Remove the challenges associated with animal models, patient-derived cells and directed differentiation protocols from your workflows, and start collecting disease-relevant data you can trust in a human context.